Epitope analysis for influenza vaccine design

被引:77
作者
Muñoz, ET
Deem, MW [1 ]
机构
[1] Rice Univ, Dept Bioengn, Houston, TX 77005 USA
[2] Rice Univ, Dept Phys & Astron, Houston, TX 77005 USA
关键词
influenza vaccine; original antigenic sin; antigenic drift;
D O I
10.1016/j.vaccine.2004.08.028
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Until now, design of the annual influenza vaccine has relied on phylogenetic or whole-sequence comparisons of the viral coat proteins hemagglutinin and neuraminidase, with vaccine effectiveness assumed to correlate monotonically to the vaccine-influenza sequence difference. We use a theory from statistical mechanics to quantify the non-monotonic immune response that results from antigenic drift in the epitopes of the hernagglutinin and neuraminidase proteins. The results explain the ineffectiveness of the 2003-2004 influenza vaccine in the United States and provide an accurate measure by which to optimize the effectiveness of future annual influenza vaccines. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1144 / 1148
页数:5
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