Muscular-skeletal cryptococcosis in a patient with idiopathic CD4+lymphopenia

被引：21

作者：

Zanelli, G ^{[1
]}

Sansoni, A ^{[1
]}

Ricciardi, B ^{[1
]}

Ciacci, C ^{[1
]}

Cellesi, C ^{[1
]}

机构：

[1] Univ Siena, Policlin LE SCOTTE, Ist Clin Malattie Infett, I-53100 Siena, Italy

来源：

MYCOPATHOLOGIA | 2001年 / 149卷 / 03期

关键词：

Cryptococcosis; immunodeficiency; lymphocytopenia; osteomyelitis; pregnancy;

D O I：

10.1023/A:1007271822625

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A healthy 27-year-old woman presented, four months after childbirth, ingravescent pain and claudication of the left lower limb. Magnetic Resonance Imaging of the lumbosacral and iliac regions showed widespread muscular-skeletal lesions. The patient underwent surgery; Cryptococcus neoformans was isolated from surgical samples. Liposomal amphotericin B, fluconazole and itraconazole were administered. Laboratory findings showed lymphocytopenia, with reduction of CD4+ lymphocytes (23 cells per cubic millimeter) in the absence of HIV infection and any other defined immunodeficiency. This is a rare case of muscular-skeletal cryptococcal infection isolated in a subject affected with idiopathic CD4+ lymphocytopenia.

引用

页码：137 / 139

页数：3

共 10 条

[1]

[Anonymous], 1992, MMWR MORB MORTAL WKL, V41, P541

[2] ISOLATED CRYPTOCOCCUS-NEOFORMANS OSTEOMYELITIS IN AN IMMUNOCOMPETENT CHILD [J].

BALDWIN, S ;

STAGNO, S ;

ODREZIN, GT ;

KELLY, DR ;

WHITLEY, RJ .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1988, 7 (04) :289-292

[3]

BEHRMAN RE, 1990, REV INFECT DIS, V12, P181

[4] Cryptococcal pneumonia complicating pregnancy [J].

Ely, EW ;

Peacock, JE ;

Haponik, EF ;

Washburn, RG .

MEDICINE, 1998, 77 (03) :153-167

[5]

GATENBY PA, 1989, LANCET, V1, P1027, DOI 10.1016/S0140-6736(89)92677-9

[6] CD4 lymphopenia in a patient with cryptococcal osteomyelitis [J].

Kumlin, U ;

Elmqvist, LG ;

Granlund, M ;

Olsen, B ;

Tarnvik, A .

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 1997, 29 (02) :205-206

[7] Cryptococcal osteomyelitis: Case report and review [J].

Liu, PYF .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1998, 30 (01) :33-35

[8] Cryptococcal rib osteomyelitis in a pediatric patient [J].

Raftopoulos, I ;

Meller, JL ;

Harris, V ;

Reyes, HM .

JOURNAL OF PEDIATRIC SURGERY, 1998, 33 (05) :771-773

[9] UNEXPLAINED OPPORTUNISTIC INFECTIONS AND CD4+ T-LYMPHOCYTOPENIA WITHOUT HIV-INFECTION - AN INVESTIGATION OF CASES IN THE UNITED-STATES [J].

SMITH, DK ;

NEAL, JJ ;

HOLMBERG, SD .

NEW ENGLAND JOURNAL OF MEDICINE, 1993, 328 (06) :373-379

[10]

Wu TT, 1999, J FORMOS MED ASSOC, V98, P621

← 1 →