Tumor necrosis factor-α and interleukin-10 contribute to immunoparalysis in patients with acute pancreatitis

被引：16

作者：

Ho, Yu-Pin ^{[1
]}

Chiu, Cheng-Tang ^{[1
]}

Sheen, I-Shyan ^{[1
]}

Tseng, Shu-Chin ^{[1
]}

Lai, Ping Chin ^{[2
]}

Ho, Shin-Yi ^{[2
]}

Chen, Wei-Ting ^{[1
]}

Lin, Tsung-Nan ^{[1
]}

Lin, Chun-Yen ^{[1
]}

机构：

[1] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Hepatogastroenterol,Linkou Med Ctr, Tao Yuan, Taiwan

[2] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Kidney Inst,Linkou Med Ctr, Tao Yuan, Taiwan

来源：

HUMAN IMMUNOLOGY | 2011年 / 72卷 / 01期

关键词：

HLA-DR (human leukocyte antigen-DR); Immunoparalysis; Interleukin-10; Tumor necrosis factor-alpha; Acute pancreatitis; ANTIGEN-DR EXPRESSION; MONOCYTE; MORTALITY; MANAGEMENT; SEVERITY;

D O I：

10.1016/j.humimm.2010.10.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Immunoparalysis, defined as downregulation of human leukocyte antigen-DR (HLA-DR) expression on monocytes, is strongly associated with septic complications of acute pancreatitis. However, the possible causes of this immunoparalysis have been largely unknown. A prospective case control study was performed in 54 patients with acute pancreatitis and 24 normal volunteers. HLA-DR expression on monocytes and serum cytokine levels were measured. In addition, monocytes from normal volunteers treated with tumor necrosis factor (TNF)-alpha in vitro were evaluated for HLA-DR expression and cytokine release. HLA-DR expression was significantly lower in patients with severe pancreatitis than in those with mild acute pancreatitis and healthy volunteers (42.28% +/- 11.49% vs. 86.85% +/- 14.56% vs. 93.92% +/- 7.40%, p < 0.0001), Pearson correlation analysis showed that serum TNF-alpha and serum interleukin-10 levels were both correlated with HLA-DR expression. In addition, exogenous TNF-alpha could enhance IL-10 secretion from normal monocytes in a dose-response manner. In addition, TNF-alpha could downregulate the HLA-DR expression on monocytes even in the presence of anti-IL-10 antibodies. Therefore, both TNF-alpha and IL-10 contributed to the development of immunoparalysis in patients with acute pancreatitis. (c) 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：18 / 23

页数：6

共 25 条

[1]

Asadullah K, 1995, Eur J Emerg Med, V2, P184, DOI 10.1097/00063110-199512000-00003

[2]

Sir Isaac Newton, sepsis, SIRS, and CARS [J].