Elevated tacrolimus trough levels in association with mycophenolate mofetil-induced diarrhea:: A case report

被引：16

作者：

Frühwirth, M ^{[1
]}

Fischer, H ^{[1
]}

Simma, B ^{[1
]}

Ellemunter, H ^{[1
]}

机构：

[1] Univ Innsbruck Hosp, Dept Pediat, A-6020 Innsbruck, Austria

来源：

PEDIATRIC TRANSPLANTATION | 2001年 / 5卷 / 02期

关键词：

mycophenolate mofetil; tacrolimus; diarrhea;

D O I：

10.1034/j.1399-3046.2001.005002132.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The combination of tacrolimus (TAC) and mycophenolate mofetil (MMF) is frequently used for immunosuppression after organ transplantation (Tx)l but the pharmacokinetics and intel actions between the two drugs are poorly elucidated. We describe here the increase of TAC trough levels during MMF-induced diarrhea in a 8-yr-old boy after kidney Tx. Early dose reduction of TAG, together with short-term monitoring of TAC trough levels in the presence of diarrhea, is recommended.

引用

页码：132 / 134

页数：3

共 14 条

[1] How to handle mycophenolate mofetil in combination with tacrolimus? [J].

Braun, F ;

Canelo, R ;

Schütz, E ;

Shipkora, M ;

Lorf, T ;

Hanack, U ;

Niedmann, D ;

Armstrong, VW ;

Oellerich, M ;

Ringe, B .

TRANSPLANTATION PROCEEDINGS, 1998, 30 (08) :4094-4095

[2]

Eades S K, 2000, Pediatr Transplant, V4, P63, DOI 10.1034/j.1399-3046.2000.00086.x

[3]

FILLER G, 1998, TRANSPL INT S1, V11, P82

[4]

HERBERT MF, 1997, ADV DRUG DELIV REV, V27, P201

[5] Drug interaction between mycophenolate mofetil and tacrolimus detectable within therapeutic mycophenolic acid monitoring in renal transplant patients [J].

Hübner, GI ;

Eismann, R ;

Sziegoleit, W .

THERAPEUTIC DRUG MONITORING, 1999, 21 (05) :536-539

[6] Metabolism of the macrolide immunosuppressant, tacrolimus, by the pig gut mucosa in the Ussing chamber [J].

Lampen, A ;

Christians, U ;

Gonschior, AK ;

Bader, A ;

Hackbarth, I ;

vonEngelhardt, W ;

Sewing, KF .

BRITISH JOURNAL OF PHARMACOLOGY, 1996, 117 (08) :1730-1734

[7]

Matsui A, 1996, ACTA PAEDIATR JAPON, V38, P699

[8]

Neu A M, 1999, Pediatr Transplant, V3, P83, DOI 10.1034/j.1399-3046.1999.00016.x

[9] Mycophenolate mofetil, microemulsion cyclosporine, and prednisone as primary immunosuppression for pediatric liver transplant recipients [J].

Renz, JF ;

Lightdale, J ;

Mudge, C ;

Bacchetti, P ;

Watson, J ;

Ascher, NL ;

Emond, JC ;

Rosenthal, P ;

Roberts, JP .

LIVER TRANSPLANTATION AND SURGERY, 1999, 5 (02) :136-143

[10] A systematic evaluation of conventional and novel transvenous pathways for defibrillation [J].

Roberts, PR ;

Allen, S ;

Smith, DC ;

Urban, JF ;

Euler, DE ;

Dahl, RW ;

Kallok, MJ ;

Morgan, JM .

JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY, 1999, 3 (03) :231-238

← 1 2 →