Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevance

被引：117

作者：

Grossmann, V. ^{[1
]}

Kohlmann, A. ^{[1
]}

Eder, C. ^{[1
]}

Haferlach, C. ^{[1
]}

Kern, W. ^{[1
]}

Cross, N. C. P. ^{[2
,3
]}

Haferlach, T. ^{[1
]}

Schnittger, S. ^{[1
]}

机构：

[1] MLL Munich Leukemia Lab, Munich, Germany

[2] Univ Southampton, Sch Med, Div Human Genet, Southampton, Hants, England

[3] Wessex Reg Genet Lab, Salisbury, Wilts, England

来源：

LEUKEMIA | 2011年 / 25卷 / 05期

关键词：

METHYLTRANSFERASE GENE EZH2; MYELODYSPLASTIC SYNDROMES; SOMATIC MUTATIONS; NEOPLASMS; ASXL1;

D O I：

10.1038/leu.2011.10

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：877 / 879

页数：4

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Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in &gt;80% of patients with TET2 and EZH2 being of high prognostic relevance

Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevance