Long noncoding RNA in genome regulation Prospects and mechanisms

被引：484

作者：

Hung, Tiffany

Chang, Howard Y. ^{[1
]}

机构：

[1] Stanford Univ, Howard Hughes Med Inst, Sch Med, Stanford, CA 94305 USA

来源：

RNA BIOLOGY | 2010年 / 7卷 / 05期

关键词：

lncRNA; HOTAIR; chromatin; metastasis; PRC2; GENE; PROTEINS; TRANSCRIPTION; CHROMOSOME; EXPRESSION; SEQUENCE;

D O I：

10.4161/rna.7.5.13216

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long noncoding RNAs (lncRNAs) are pervasively transcribed and critical regulators of the epigenome. 1,2 These long, polyadenylated RNAs do not code for proteins, but function directly as RNAs, recruiting chromatin modifiers to mediate transcriptional changes in processes ranging from X-inactivation (XIST) to imprinting (H19). 3 The recent discovery that lncRNA HOTAIR can link chromatin changes to cancer metastasis(4) furthers the relevance of lncRNAs to human disease. Here, we discuss lncRNAs as regulatory modules and explore the implications for disease pathogenesis.

引用

页码：582 / 585

页数：4

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