Probiotics and other preventative strategies for necrotising enterocolitis

被引:14
作者
Embleton, Nicholas D. [1 ]
Yates, Rowena [1 ]
机构
[1] Royal Victoria Infirm, Newcastle Neonatal Serv, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England
关键词
breast milk; feeding; guidelines; infant; newborn; necrotising; enterocolitis; probiotics;
D O I
10.1016/j.siny.2007.09.003
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Necrotising enterocolitis (NEC) remains one of the commonest causes of death and significant morbidity in preterm infants after the first few postnatal days. NEC affects approximately 5-10% of infants born at <= 28 weeks; about a third will die. Although there do not appear to be any 'simple fixes', it is clear that there are many clinical strategies that affect NEC. There is controlled trial evidence for breast milk, fluid regimes, enteral antibiotics, immuno-nutrients and probiotic supplements. This paper will review the evidence relevant to current populations of preterm infants and determine which, if any, can be safety and effectively introduced into current clinical practice. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:35 / 43
页数:9
相关论文
共 77 条
[1]   Effects of oral Lactobacillus GG on enteric microflora in low-birth-weight neonates [J].
Agarwal, R ;
Sharma, N ;
Chaudhry, R ;
Deorari, A ;
Paul, VK ;
Gewolb, IH ;
Panigrahi, P .
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2003, 36 (03) :397-402
[2]   Neonatal necrotising enterocolitis and perinatal exposure to co-amoxyclav [J].
Al-Sabbagh, A ;
Moss, S ;
Subhedar, N .
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 2004, 89 (02) :187-187
[3]   Arginine supplementation prevents necrotizing enterocolitis in the premature infant [J].
Amin, HJ ;
Zamora, SA ;
McMillan, DD ;
Fick, GH ;
Butzner, JD ;
Parsons, HG ;
Scott, RB .
JOURNAL OF PEDIATRICS, 2002, 140 (04) :425-431
[4]  
BELL EF, 1980, NEW ENGL J MED, V302, P598, DOI 10.1056/NEJM198003133021103
[5]   Preventing necrotizing enterocolitis: What works and how safe? [J].
Bell, EF .
PEDIATRICS, 2005, 115 (01) :173-174
[6]  
Bell EF, 2001, COCHRANE DB SYST REV, V2
[7]   NEONATAL NECROTIZING ENTEROCOLITIS - THERAPEUTIC DECISIONS BASED UPON CLINICAL STAGING [J].
BELL, MJ ;
TERNBERG, JL ;
FEIGIN, RD ;
KEATING, JP ;
MARSHALL, R ;
BARTON, L ;
BROTHERTON, T .
ANNALS OF SURGERY, 1978, 187 (01) :1-7
[8]   Prolonging small feeding volumes early in life decreases the incidence of necrotizing enterocolitis in very low birth weight infants [J].
Berseth, CL ;
Bisquera, JA ;
Paje, VU .
PEDIATRICS, 2003, 111 (03) :529-534
[9]   Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates [J].
Bin-Nun, A ;
Bromiker, R ;
Wilschanski, M ;
Kaplan, M ;
Rudensky, B ;
Caplan, M ;
Hammerman, C .
JOURNAL OF PEDIATRICS, 2005, 147 (02) :192-196
[10]   Nosocomial necrotising enterocolitis outbreaks: epidemiology and control measures [J].
Boccia, D ;
Stolfi, I ;
Lana, S ;
Moro, ML .
EUROPEAN JOURNAL OF PEDIATRICS, 2001, 160 (06) :385-391