Testosterone Deficiency and Risk Factors in the Metabolic Syndrome: Implications for Erectile Dysfunction

被引：26

作者：

Guay, Andre T. ^{[1
,2
]}

Traish, Abdulmaged ^{[3
,4
]}

机构：

[1] Lahey Clin Fdn, Ctr Sexual Funct, Dept Endocrinol, Peabody, MA 01960 USA

[2] Tufts Univ, Sch Med, Boston, MA 02111 USA

[3] Boston Univ, Sch Med, Dept Biochem, Boston, MA 02118 USA

[4] Boston Univ, Sch Med, Dept Urol, Boston, MA 02118 USA

来源：

UROLOGIC CLINICS OF NORTH AMERICA | 2011年 / 38卷 / 02期

关键词：

Hypogonadism; Metabolic syndrome; Endothelial dysfunction; Erectile dysfunction; Testosterone; MIDDLE-AGED MEN; HORMONE-BINDING-GLOBULIN; DEPENDENT DIABETES-MELLITUS; ENDOGENOUS SEX-HORMONES; LOW SERUM TESTOSTERONE; INSULIN-RESISTANCE; ELDERLY-MEN; HYPOGONADAL MEN; ANDROGEN LEVELS; REPLACEMENT THERAPY;

D O I：

10.1016/j.ucl.2011.02.004

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The most common cause of erectile dysfunction (ED) is penile vascular insufficiency. This is usually part of a generalized endothelial dysfunction and is related to several conditions, including type 2 diabetes mellitus, hypertension, hyperlipidemia, and obesity. These conditions underlie the pathophysiology of metabolic syndrome (MetS). Hypogonadism, or testosterone deficiency (TD), is an integral component of the pathology underlying endothelial dysfunction and MetS, with insulin resistance (IR) at its core. Testosterone replacement therapy for TD has been shown to ameliorate some of the components of the MetS, improve IR, and may serve as treatment for decreasing cardiovascular and ED risk.

引用

页码：175 / +

页数：11

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