Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) pathway signaling

被引：82

作者：

Thorburn, Andrew

机构：

[1] Univ Colorado Denver, Ctr Comprehens Canc, Aurora, CO 80010 USA

[2] Dept Pharmacol, Aurora, CO USA

[3] Hlth Sci Ctr, Aurora, CO USA

来源：

JOURNAL OF THORACIC ONCOLOGY | 2007年 / 2卷 / 06期

关键词：

D O I：

10.1097/JTO.0b013e31805fea64

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/ ApolL is a death ligand, a cytokine that activates apoptosis through cell surface death receptors. TRAIL is thought to be important in host tumor surveillance and metastasis suppression, and various therapeutic agonists that activate TRAIL receptors to induce tumor cell apoptosis are in clinical development. This review discusses recent findings about TRAIL pathway signaling and relates the signaling mechanisms to issues that need to be considered as we try to manipulate TRAIL signaling to treat cancer.

引用

页码：461 / 465

页数：5

共 66 条

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[10]

DELMAS D, ONCOGENE, V23, P8979

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