Lithium naphthalenide induced reductive alkylation of α-cyano ketones.: A general method for regiocontrol of α,α-dialkylation of ketones

被引：24

作者：

Liu, HJ ^{[1
]}

Zhu, JL

Shia, KS

机构：

[1] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada

[2] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30043, Taiwan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 24期

基金：

加拿大自然科学与工程研究理事会;

关键词：

carbonyl compounds; alkylation; regiocontrol;

D O I：

10.1016/S0040-4039(98)00780-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient general method for the consecutive introduction of two alkyl groups to the alpha carbon of a ketone carbonyl has been developed, making use of the lithium naphthalenide induced reductive alkylation of an alpha-cyano ketone system as a key operation. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：4183 / 4186

页数：4

共 15 条

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