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Characterization of CD56-/CD16+ natural killer (NK) cells:: A highly dysfunctional NK subset expanded in HIV-infected viremic individuals

被引：415
作者：
Mavilio, D
Lombardo, G
Benjamin, J
Kim, D
Follman, D
Marcenaro, E
O'Shea, MA
Kinter, A
Kovacs, C
Moretta, A
Fauci, AS
机构：
[1] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA
[2] NIAID, Biostat Res Branch, NIH, Bethesda, MD 20892 USA
[3] Univ Genoa, Dipartimento Med Sperimentale, I-16132 Genoa, Italy
[4] Univ Toronto, Dept Med, Toronto, ON M5S 1A1, Canada
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2005年 / 102卷 / 08期
关键词：
cytokines; cytotoxicity; inhibitory NK receptors; killer immunoglobulin-like receptors; natural cytotoxicity receptors;
D O I：
10.1073/pnas.0409872102
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Natural killer (NK) cells are an important component of the innate immune response against viral infections. INK cell-mediated cytolytic activity is defective in HIV-infected individuals with high levels of viral replication. In the present study, we examined the phenotypic and functional characteristics of an unusual CD56(-)/CD16(+) (CD56(-)) NK subset that is greatly expanded in HIV-viremic individuals. The higher level of expression of inhibitory INK receptors and the lower level of expression of natural cytotoxicity receptors observed in the CD56- INK fraction compared with that of CD56(+) NK cells was associated with extremely poor in vitro cytotoxic function of this subset. in addition, the secretion of certain cytokines known to be important in initiating antiviral immune responses was markedly reduced in the CD56-, as compared with the CD56+ NK cell subset. These data suggest that the expansion of this highly dysfunctional CD56- NK cell subset in HIV-viremic individuals largely accounts for the impaired function of the total INK cell population.
引用
收藏
页码：2886 / 2891
页数：6
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