Syntheses of pyrrolo- and indoloisoquinolinones by intramolecular cyclizations of 1-(2-arylethyl)-5-benzotriazolylpyrrolidin-2-ones and 3-benzotriazolyl-2-(2-arylethyl)-1-isoindolinones

被引：81

作者：

Katritzky, AR ^{[1
]}

Mehta, S ^{[1
]}

He, HY ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Chem, Gainesville, FL 32611 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 66卷 / 01期

关键词：

D O I：

10.1021/jo001273f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

.1,5,6, 10b-Tetrahydropyrrolo[2,1-alpha ]isoquinolin-3(2H)-ones 17a,b, 17d,e, and 5,12b-dihydroisoindolo-[1,2-alpha ]isoquinolin-8(6H)-ones 22a-e were prepared by intramolecular cyclizations of 1-(2-arylethyl)-5-benzotriazolyl-pyrrolidin-2-ones 15a,b, 15d,e, and 3-benzotriazolyl-2-(2-arylethyl)-1-isoindolinones 20a-e, respectively, in the presence of titanium chloride. Products from chiral amines were obtained with stereoselectivities of greater than or equal to 94%.

引用

页码：148 / 152

页数：5

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