Correlation of statin-increased platelet APP ratios and reduced blood lipids in AD patients

被引：30

作者：

Baskin, F

Rosenberg, RN

Fang, X

Hynan, LS

Moore, CB

Weiner, M

Vega, GL

机构：

[1] Univ Texas, SW Med Ctr, Dept Neurol, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, Dept Psychiat, Dallas, TX 75390 USA

[3] Univ Texas, SW Med Ctr, Acad Comp Serv, Dallas, TX 75390 USA

[4] Univ Texas, SW Med Ctr, Ctr Human Nutr & Clin Nutr, Dallas, TX 75390 USA

来源：

NEUROLOGY | 2003年 / 60卷 / 12期

关键词：

D O I：

10.1212/01.WNL.0000068029.56740.96

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Platelets, like neurons, contain 120- to 130- and 110-kd amyloid precursor proteins (APPs). Their ratio is reduced in AD, further reductions correlating with reduced Mini-Mental Status Examination scores [r(11) = 0.69, p < 0.05]. As statins alter APP processing, platelet APPs were analyzed in patients with AD given anticholesterol drugs for 6 weeks. APP ratios increased [t(37) = -3.888, p = 0.0004], proportionally with reduced cholesterol [r(36) = -0.45, p = 0.005]. Longer trials may reveal slowed cognitive loss, validating this index.

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页码：2006 / 2007

页数：2

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