Endothelial nitric oxide synthase gene sequence variations and vascular disease

被引：165

作者：

Wang, XL ^{[1
]}

Wang, J ^{[1
]}

机构：

[1] SW Fdn Biomed Res, Dept Genet, San Antonio, TX 78227 USA

来源：

MOLECULAR GENETICS AND METABOLISM | 2000年 / 70卷 / 04期

关键词：

stroke; coronary artery disease; hypertension; renal disease; eNOS polymorphism; cigarette smoking;

D O I：

10.1006/mgme.2000.3033

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Genes contribute significantly to interpopulation differences in vascular disease, Endothelial nitric oxide synthase (eNOS)-a key regulator of vascular nitric oxide production-has been investigated extensively to determine the relevance of DNA variants in the eNOS gene and vascular diseases. Variants in the promoter region, introns, and exons have been explored in a large number of populations but findings have been inconsistent. This paper reviews the current status of functional significance for reported sequence variations in the eNOS gene and the relevance of these variants to different forms of vascular diseases. (C) 2000 Academic Press.

引用

页码：241 / 251

页数：11

共 83 条

[1] Endothelial nitric oxide synthase intron 4, 27 bp repeat polymorphism in Turkish patients with deep vein thrombosis and cerebrovascular accidents [J].

Akar, N ;

Akar, E ;

Cin, S ;

Deda, G ;

Avcu, F ;

Yalçin, A .

THROMBOSIS RESEARCH, 1999, 94 (01) :63-64

[2] Endothelial cytosolic proteins bind to the 3' untranslated region of endothelial nitric oxide synthase mRNA: Regulation by tumor necrosis factor alpha [J].

Alonso, J ;

deMiguel, LS ;

Monton, M ;

Casado, S ;

LopezFarre, A .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (10) :5719-5726

[3] Enzymatic function of nitric oxide synthases [J].

Andrew, PJ ;

Mayer, B .

CARDIOVASCULAR RESEARCH, 1999, 43 (03) :521-531

[4]

Antonarakis SE, 1998, HUM MUTAT, V11, P1

[5] Soluble vascular cell adhesion molecule-1 and E-selectin levels in relation to vascular risk factors and to E-selectin genotype in the first degree relatives of NIDDM patients and in NIDDM patients [J].

Bannan, S ;

Mansfield, MW ;

Grant, PJ .

DIABETOLOGIA, 1998, 41 (04) :460-466

[6]

Beckman JS, 1996, AM J PHYSIOL-CELL PH, V271, pC1424

[7]

BENJAFIELD AV, 2000, IN PRESS AM J HYPERT

[8] Regulation of endothelial NO synthase mRNA stability -: RNA-binding proteins crowd on the 3′-untranslated region [J].

Bloch, KD .

CIRCULATION RESEARCH, 1999, 85 (07) :653-655

[9] LACK OF EVIDENCE FOR LINKAGE OF THE ENDOTHELIAL-CELL NITRIC-OXIDE SYNTHASE GENE TO ESSENTIAL-HYPERTENSION [J].

BONNARDEAUX, A ;

NADAUD, S ;

CHARRU, A ;

JEUNEMAITRE, X ;

CORVOL, P ;

SOUBRIER, F .

CIRCULATION, 1995, 91 (01) :96-102

[10]

Burg M, 1997, CLIN NEPHROL, V48, P205

← 1 2 3 4 5 6 7 8 9 →