Enhanced immune responses and resistance against infection in aged mice conferred by Flu-ISCOMs vaccine correlate with up-regulation of costimulatory molecule CD86

被引：17

作者：

Sambhara, S ^{[1
]}

Kurichh, A ^{[1
]}

Miranda, R ^{[1
]}

Tamane, A ^{[1
]}

Arpino, R ^{[1
]}

James, O ^{[1
]}

McGuinness, U ^{[1
]}

Kandil, A ^{[1
]}

Underdown, B ^{[1
]}

Klein, M ^{[1
]}

Burt, D ^{[1
]}

机构：

[1] Pasteur Merieux Connaught Canada, Res Ctr, N York, ON M2R 3T4, Canada

来源：

VACCINE | 1998年 / 16卷 / 18期

关键词：

influenza-ISCOMs; immunosenescence; co-stimulation;

D O I：

10.1016/S0264-410X(98)00130-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ageing is associated with a decline in immune function and our primary objective is to 'reverse' age-related decline in. protective immune responses to vaccination by formulating vaccines in appropriate delivery systems. In this paper we demonstrate that influenza vaccine formulated as ISCOMs is highly immunogenic and confers protection in aged mice, when compared to current influenza vaccine. The enhanced protection conferred by Flu-ISCOMs in aged mice correlates with the up-regulation of co-stimulatory molecule, CD86 (B7.2) and to a lesser extent, CD80 (B7.2) expression on antigen presenting cells. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1698 / 1704

页数：7

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