DXS101: a highly polymorphic X-linked STR

被引：42

作者：

Edelmann, J

Szibor, R

机构：

[1] Univ Leipzig, Inst Legal Med, D-04103 Leipzig, Germany

[2] Otto Von Guericke Univ, Inst Legal Med, D-39120 Magdeburg, Germany

来源：

INTERNATIONAL JOURNAL OF LEGAL MEDICINE | 2001年 / 114卷 / 4-5期

关键词：

short tandem repeat; X-chromosome; kinship resting;

D O I：

10.1007/s004140000188

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

This paper presents sequence and population genetic data for the microsatellite marker DXS101 which is a highly polymorphic X-linked trinucleotide polymorphism with 18 alleles 179-233 bp in length. A polymorphism information content (PIC) of 0.884 and a mean exclusion chance (MEC) of 0.879 were obtained by analysing a Caucasian population sample. A deviation from the Hardy-Weinberg equilibrium (HWE) could not be detected. Kinship tests revealed a typical X-linked inheritance and no mutations were found in 340 meioses. DXS 101 is located 104.9-121 cM from the XF-telomere (Xp-tel) corresponding to Xq21.33-Xq22.3. Concomitant testing of DXS 101 and DXS6X07 is possible as these two markers are unlinked. The data presented qualify this X-linked microsatellite marker as a useful tool fur forensic purposes.

引用

页码：301 / 304

页数：4

共 24 条

[1] TRINUCLEOTIDE REPEAT POLYMORPHISM AT DXS101 [J].

ALLEN, RC ;

BELMONT, JW .

HUMAN MOLECULAR GENETICS, 1993, 2 (09) :1508-1508

[2] DNA recommendations - Further report of the DNA Commission of the ISFH regarding the use of short tandem repeat systems [J].

Bar, W ;

Brinkmann, B ;

Budowle, B ;

Carracedo, A ;

Gill, P ;

Lincoln, P ;

Mayr, W ;

Olaisen, B .

INTERNATIONAL JOURNAL OF LEGAL MEDICINE, 1997, 110 (04) :175-176

[3]

BOTSTEIN D, 1980, AM J HUM GENET, V32, P314

[4]

Brinkmann B, 1998, Methods Mol Biol, V98, P105

[5] Mutation rate in human microsatellites:: Influence of the structure and length of the tandem repeat [J].

Brinkmann, B ;

Klintschar, M ;

Neuhuber, F ;

Hühne, J ;

Rolf, B .

AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 62 (06) :1408-1415

[6] A physical map of 30,000 human genes [J].

Deloukas, P ;

Schuler, GD ;

Gyapay, G ;

Beasley, EM ;

Soderlund, C ;

Rodriguez-Tomé, P ;

Hui, L ;

Matise, TC ;

McKusick, KB ;

Beckmann, JS ;

Bentolila, S ;

Bihoreau, MT ;

Birren, BB ;

Browne, J ;

Butler, A ;

Castle, AB ;

Chiannilkulchai, N ;

Clee, C ;

Day, PJR ;

Dehejia, A ;

Dibling, T ;

Drouot, N ;

Duprat, S ;

Fizames, C ;

Fox, S ;

Gelling, S ;

Green, L ;

Harrison, P ;

Hocking, R ;

Holloway, E ;

Hunt, S ;

Keil, S ;

Lijnzaad, P ;

Louis-Dit-Sully, C ;

Ma, J ;

Mendis, A ;

Miller, J ;

Morissette, J ;

Muselet, D ;

Nusbaum, HC ;

Peck, A ;

Rozen, S ;

Simon, D ;

Slonim, DK ;

Staples, R ;

Stein, LD ;

Stewart, EA ;

Suchard, MA ;

Thangarajah, T ;

Vega-Czarny, N .

SCIENCE, 1998, 282 (5389) :744-746

[7]

Desmarais D, 1998, J FORENSIC SCI, V43, P1046

[8]

Edelmann J, 1999, ELECTROPHORESIS, V20, P2844, DOI 10.1002/(SICI)1522-2683(19991001)20:14<2844::AID-ELPS2844>3.0.CO

[9]

2-D

[10] PERFORMING THE EXACT TEST OF HARDY-WEINBERG PROPORTION FOR MULTIPLE ALLELES [J].

GUO, SW ;

THOMPSON, EA .

BIOMETRICS, 1992, 48 (02) :361-372

← 1 2 3 →