Why Don't CD8+T Cells Reduce the Lifespan of SIV-Infected Cells In Vivo?

被引：25

作者：

Elemans, Marjet ^{[1
]}

al Basatena, Nafisa-Katrin Seich ^{[1
]}

Klatt, Nichole R. ^{[2
]}

Gkekas, Christos ^{[1
]}

Silvestri, Guido ^{[3
]}

Asquith, Becca ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Immunol, London, England

[2] NIAID, Mol Microbiol Lab, NIH, Bethesda, MD 20892 USA

[3] Emory Univ, Sch Med, Atlanta, GA USA

来源：

PLOS COMPUTATIONAL BIOLOGY | 2011年 / 7卷 / 09期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

IMMUNODEFICIENCY VIRUS-INFECTION; CYTOTOXIC T-LYMPHOCYTES; TYPE-1; INFECTION; REPLICATION; DYNAMICS; INDIVIDUALS; INHIBITOR; TURNOVER; MACAQUES; VIREMIA;

D O I：

10.1371/journal.pcbi.1002200

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In January 2010 two groups independently published the observation that the depletion of CD8+ cells in SIV-infected macaques had no detectable impact on the lifespan of productively infected cells. This unexpected observation led the authors to suggest that CD8+ T cells control SIV viraemia via non-lytic mechanisms. However, a number of alternative plausible explanations, compatible with a lytic model of CD8+ T cell control, were proposed. This left the field with no consensus on how to interpret these experiments and no clear indication whether CD8+ T cells operated primarily via a lytic or a non-lytic mechanism. The aim of this work was to investigate why CD8+ T cells do not appear to reduce the lifespan of SIV-infected cells in vivo.

引用

页数：8

共 31 条

[1] Implications of CTL-Mediated Killing of HIV-Infected Cells during the Non-Productive Stage of Infection [J].

Althaus, Christian L. ;

De Boer, Rob J. .

PLOS ONE, 2011, 6 (02)

[2] An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses [J].

André, P ;

Groettrup, M ;

Klenerman, P ;

de Giuli, R ;

Booth, BL ;

Cerundolo, V ;

Bonneville, M ;

Jotereau, F ;

Zinkernagel, RM ;

Lotteau, V .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) :13120-13124

[3]

[Anonymous], 2002, Model selection and multimodel inference: a practical informationtheoretic approach

[4]

[Anonymous], 2005, R LANG ENV STAT COMP

[5] Inefficient cytotoxic T lymphocyte-mediated killing of HIV-1-infected cells in vivo [J].

Asquith, B ;

Edwards, CTT ;

Lipsitch, M ;

McLean, AR .

PLOS BIOLOGY, 2006, 4 (04) :583-592

[6] In vivo CD8+ T cell control of immunodeficiency virus infection in humans and macaques [J].

Asquith, Becca ;

McLean, Angela R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (15) :6365-6370

[7]

Bates D. M., 1988, Nonlinear regression analysis and its applications, V2

[8] CD8+ T cell concentration determines their efficiency in killing cognate antigen expressing syngeneic mammalian cells in vitro and in mouse tissues [J].

Budhu, Sadna ;

Loike, John D. ;

Pandolfi, Ashley ;

Han, Soo ;

Catalano, Geoffrey ;

Constantinescu, Andrei ;

Clynes, Raphael ;

Silverstein, Samuel C. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (01) :223-235

[9] Autocrine Production of β-Chemokines Protects CMV-Specific CD4+ T Cells from HIV Infection [J].

Casazza, Joseph P. ;

Brenchley, Jason M. ;

Hill, Brenna J. ;

Ayana, Ribka ;

Ambrozak, David ;

Roederer, Mario ;

Douek, Daniel C. ;

Betts, Michael R. ;

Koup, Richard A. .

PLOS PATHOGENS, 2009, 5 (10)

[10] The HIV protease inhibitor Indinavir inhibits cell-cycle progression in vitro in lymphocytes of HIV-infected and uninfected individuals [J].

Chavan, S ;

Kodoth, S ;

Pahwa, R ;

Pahwa, S .

BLOOD, 2001, 98 (02) :383-389

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