XPD exon 10 and 23 polymorphisms and DNA repair in human skin in situ

被引:79
作者
Hemminki, K [1 ]
Xu, GG
Angelini, S
Snellman, E
Jansen, CT
Lambert, B
Hou, SM
机构
[1] Karolinska Inst, Novum, Dept Biosci, S-14157 Huddinge, Sweden
[2] Paijat Hame Cent Hosp, Dept Dermatol, Lahti 15850, Finland
[3] Turku Univ, Dept Dermatol, Turku 20520, Finland
关键词
D O I
10.1093/carcin/22.8.1185
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Forty-four Finnish volunteers who were previously studied with regard to the repair rate of UV-specific cyclobutane pyrimidine dimers in the skin were genotyped for XPD polymorphisms at codons 312 (exon 10 G -->A, Asp --> Asn) and 751 (exon 23 A -->C, Lys --> Gln). The repair rate was measured at 24 h for two different cyclobutane dimers. The data did not show consistent XPD genotype-specific differences in DNA repair rates among all subjects. The combined exon 10 AA and exon 23 CC genotype was associated with an similar to 50% depression of repair rate but this was of borderline statistical significance. However, the exon 23 C allele was associated with depressed repair among subjects aged 50 years or older and the result was consistent with both dimers.
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收藏
页码:1185 / 1188
页数:4
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