Association between tumor necrosis factor-α promoter polymorphism and Alzheimer's disease

被引：29

作者：

Ma, SL

Tang, NLS

Lam, LCW ^{[1
]}

Chiu, HFK

机构：

[1] Chinese Univ Hong Kong, Fac Med, Dept Psychiat, Shatin, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Fac Med, Dept Chem Pathol, Shatin, Hong Kong, Peoples R China

来源：

NEUROLOGY | 2004年 / 62卷 / 02期

关键词：

D O I：

10.1212/01.WNL.0000103288.49441.E4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Tumor necrosis factor-alpha (TNFalpha) gene polymorphisms have been reported to be associated with Alzheimer's disease (AD) in Caucasian populations. Three TNFalpha polymorphisms (-857, -863, and -1,031) were studied in a Chinese population. A high-risk TNFalpha haplotype (-1,031C-863C-857C) with an odds ratio of 2.54 (95% CI 1.37 to 4.79) for AD was identified. No interaction effect of APOE and TNFalpha genotypes was found, but both acted as important risk factors for AD.

引用

页码：307 / 309

页数：3

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