Brief report - Smoking and osteoarthritis: Differential effect of nicotine on human chondrocyte glycosaminoglycan and collagen synthesis

被引：52

作者：

Gullahorn, L ^{[1
]}

Lippiello, L ^{[1
]}

Karpman, R ^{[1
]}

机构：

[1] Maricopa Cty Gen Hosp, Orthopaed Res Program, Phoenix, AZ 85006 USA

来源：

OSTEOARTHRITIS AND CARTILAGE | 2005年 / 13卷 / 10期

关键词：

nicotine; osteoarthritis; cartilage metabolism; smoking;

D O I：

10.1016/j.joca.2005.03.001

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Anecdotal suggestions and retrospective studies indicate an inverse relationship between the incidence of osteoarthritis and individuals who smoke. As a possible explanation, our studies confirm that nicotine upregulates glycosaminoglycan and collagen synthetic activity of articular chondrocytes at physiological levels seen in individuals who smoke. (c) 2005 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

引用

页码：942 / 943

页数：2

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