Selective versus total insulin resistance: A pathogenic paradox

被引：728

作者：

Brown, Michael S. ^{[1
]}

Goldstein, Joseph L. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Mol Genet, Dallas, TX 75390 USA

来源：

CELL METABOLISM | 2008年 / 7卷 / 02期

关键词：

D O I：

10.1016/j.cmet.2007.12.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mice with type 2 diabetes manifest selective hepatic insulin resistance: insulin fails to suppress gluconeogenesis but continues to activate lipogenesis, producing the deadly combination of hyperglycemia and hypertriglyceridemia. In this issue of Cell Metabolism, Biddinger et al. (2008) show that mice with total hepatic insulin resistance exhibit hyperglycemia without hypertriglyceridemia-a state paradoxically less severe than selective insulin resistance.

引用

页码：95 / 96

页数：2

共 11 条

[1] From mice to men: Insights into the insulin resistance syndromes
Biddinger, SB
Kahn, CR
[J]. ANNUAL REVIEW OF PHYSIOLOGY, 2006, 68 : 123 - 158
[2] Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis
Biddinger, Sudha B.
Hernandez-Ono, Antonio
Rask-Madsen, Christian
Haas, Joel T.
Aleman, Jose O.
Suzuki, Ryo
Scapa, Erez F.
Agarwal, Chhavi
Carey, Martin C.
Stephanopoulos, Gregory
Cohen, David E.
King, George L.
Ginsberg, Henry N.
Kahn, C. Ronald
[J]. CELL METABOLISM, 2008, 7 (02) : 125 - 134
[3] The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
Brown, MS
Goldstein, JL
[J]. CELL, 1997, 89 (03) : 331 - 340
[4] SREBP-1c transcription factor and lipid homeostasis:: Clinical perspective
Ferre, P.
Foufelle, F.
[J]. HORMONE RESEARCH, 2007, 68 (02) : 72 - 82
[5] SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, JD
Goldstein, JL
Brown, MS
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (09) : 1125 - 1131
[6] BETA-CELL LIPOTOXICITY IN THE PATHOGENESIS OF NON-INSULIN-DEPENDENT DIABETES-MELLITUS OF OBESE RATS - IMPAIRMENT IN ADIPOCYTE-BETA-CELL RELATIONSHIPS
LEE, Y
HIROSE, H
OHNEDA, M
JOHNSON, JH
MCGARRY, JD
UNGER, RH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (23) : 10878 - 10882
[7] Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism
Matsumoto, Michihiro
Han, Seongah
Kitamura, Tadahiro
Accili, Domenico
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (09) : 2464 - 2472
[8] WHAT IF MINKOWSKI HAD BEEN AGEUSIC - AN ALTERNATIVE ANGLE ON DIABETES
MCGARRY, JD
[J]. SCIENCE, 1992, 258 (5083) : 766 - 770
[9] Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
Michael, MD
Kulkarni, RN
Postic, C
Previs, SF
Shulman, GI
Magnuson, MA
Kahn, CR
[J]. MOLECULAR CELL, 2000, 6 (01) : 87 - 97
[10] Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
Shimomura, I
Matsuda, M
Hammer, RE
Bashmakov, Y
Brown, MS
Goldstein, JL
[J]. MOLECULAR CELL, 2000, 6 (01) : 77 - 86

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