The V1a vasopressin receptor is necessary and sufficient for normal social recognition: A gene replacement study

被引:271
作者
Bielsky, IF [1 ]
Hu, SB
Ren, XH
Terwilliger, EF
Young, LJ
机构
[1] Emory Univ, Dept Psychiat, Atlanta, GA 30329 USA
[2] Emory Univ, Ctr Behav Neurosci, Atlanta, GA 30329 USA
[3] NIMH, Clin Neuroendocrinol Branch, NIH, Bethesda, MD 20892 USA
[4] Harvard Univ, Inst Med, Boston, MA 02115 USA
[5] Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA
关键词
D O I
10.1016/j.neuron.2005.06.031
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Vasopressin modulates many social and nonsocial behaviors, including emotionality. We have previously reported that male mice with a null mutation in the V1a receptor (V1aR) exhibit a profound impairment in social recognition and changes in anxiety-like behavior. Using site-specific injections of a V1aR-specific antagonist, we demonstrate that the lateral septum, but not the medial amygdala, is critical for social recognition. Reexpressing V1aR in the lateral septum of V1aR knockout mice (V1aRKO) using a viral vector resulted in a complete rescue of social recognition. Furthermore, overexpression of the V1aR in the lateral septum of wild-type (wt) mice resulted in a potentiation of social recognition behavior and a mild increase in anxiety-related behavior. These results demonstrate that the V1aR in the lateral septum plays a critical role in the neural processing of social stimuli required for complex social behavior.
引用
收藏
页码:503 / 513
页数:11
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