Magnetic biosensors for genetic screening of cystic fibrosis

被引：24

作者：

Lagae, L

Wirix-Speetjens, R

Liu, CX

Laureyn, W

Borghs, G

Harvey, S

Galvin, P

Ferreira, HA

Graham, DL

Freitas, PP

Clarke, LA

Amaral, MD

机构：

[1] IMEC, MCP, B-3000 Louvain, Belgium

[2] Tyndall Natl Inst, Cork, Ireland

[3] INESC, Lisbon, Portugal

[4] Univ Lisbon, Fac Sci, Dept Chem & Biochem, P-1699 Lisbon, Portugal

来源：

IEE PROCEEDINGS-CIRCUITS DEVICES AND SYSTEMS | 2005年 / 152卷 / 04期

关键词：

D O I：

10.1049/ip-cds:20050022

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

The paper reports on the development of a magnetic biosensing platform for genetic analysis. The sensing technique is based on the on-chip manipulation of magnetically labelled biomolecules by the magnetic field gradient force created by current-carrying conductors; on biomolecular reactions such as the binding of complementary DNA material; and on the detection of the fringe field of the magnetic label by a magnetoresistive spin valve sensor. Different experiments will demonstrate the advantages, difficulties, prospects and potential of the combination of magnetic bead manipulation and detection on a single microchip. Early detection of DNA coding for the cystic fibrosis (CF) gene is used as a model system for proof-of-concept of the magnetic DNA biosensor platform.

引用

页码：393 / 400

页数：8

共 21 条

[1] A biosensor based on magnetoresistance technology [J].