Intake of Japanese and Chinese teas reduces risk of Parkinson's disease

被引：65

作者：

Tanaka, Keiko ^{[1
]}

Miyake, Yoshihiro ^{[1
]}

Fukushima, Wakaba ^{[2
]}

Sasaki, Satoshi ^{[3
]}

Kiyohara, Chikako ^{[4
]}

Tsuboi, Yoshio ^{[5
]}

Yamada, Tatsuo ^{[5
]}

Oeda, Tomoko ^{[6
]}

Miki, Takami ^{[7
]}

Kawamura, Nobutoshi ^{[8
]}

Sakae, Nobutaka ^{[8
]}

Fukuyama, Hidenao ^{[9
]}

Hirota, Yoshio ^{[2
]}

Nagai, Masaki ^{[10
]}

机构：

[1] Fukuoka Univ, Fac Med, Dept Publ Hlth, Fukuoka 8140180, Japan

[2] Osaka City Univ, Grad Sch Med, Dept Publ Hlth, Osaka 558, Japan

[3] Univ Tokyo, Sch Publ Hlth, Dept Social & Prevent Epidemiol, Tokyo, Japan

[4] Kyushu Univ, Grad Sch Med Sci, Dept Prevent Med, Fukuoka 812, Japan

[5] Fukuoka Univ, Fac Med, Dept Neurol, Fukuoka 8140180, Japan

[6] Natl Utano Hosp, Dept Neurol, Kyoto, Japan

[7] Osaka City Univ, Grad Sch Med, Dept Geriatr Med, Osaka 558, Japan

[8] Kyushu Univ, Grad Sch Med Sci, Dept Neurol, Fukuoka 812, Japan

[9] Kyoto Univ, Grad Sch Med, Human Brain Res Ctr, Kyoto, Japan

[10] Saitama Med Univ, Fac Med, Dept Publ Hlth, Saitama, Japan

来源：

PARKINSONISM & RELATED DISORDERS | 2011年 / 17卷 / 06期

关键词：

Caffeine; Case-control studies; Coffee; Japan; Parkinson's disease; CAFFEINE INTAKE; COFFEE CONSUMPTION; CIGARETTE-SMOKING; SWEDISH TWINS; METAANALYSIS; ESTROGEN; ALCOHOL; COHORT;

D O I：

10.1016/j.parkreldis.2011.02.016

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Studies that have addressed the association between the intake of coffee or caffeine and Parkinson's disease (PD) were conducted mainly in Western countries. Little is known about this relationship in an Asian population. Therefore, we performed an assessment of the association of the intake of coffee, other caffeine-containing beverages, and caffeine with the risk of PD in Japan. The study involved 249 PD cases and 368 control subjects. Information on dietary factors was obtained through a self-administered diet history questionnaire. Adjustment was made for sex, age, region of residence, educational level, pack-years of smoking, body mass index, the dietary glycemic index, and intake of cholesterol, vitamin E, It-carotene, vitamin B(6), alcohol, and iron. Intake of coffee, black tea, and Japanese and Chinese teas was significantly inversely associated with the risk of PD: the adjusted odds ratios in comparison of the highest with the lowest quartile were 0.52, 0.58, and 0.59, respectively (95% confidence intervals = 0.30-0.90, 035-0.97, and 0.35-0.995, respectively). A clear inverse dose response relationship between total caffeine intake and PD risk was observed. We confirmed that the intake of coffee and caffeine reduced the risk of PD. Furthermore, this is the first study to show a significant inverse relationship between the intake of Japanese and Chinese teas and the risk of PD. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：446 / 450

页数：5

共 30 条

[1] Frequency of bowel movements and the future risk of Parkinson's disease [J].