Selenium and Lung Cancer: A Systematic Review and Meta Analysis

被引:62
作者
Fritz, Heidi [1 ]
Kennedy, Deborah [1 ,2 ]
Fergusson, Dean
Fernandes, Rochelle [1 ,3 ]
Cooley, Kieran [1 ,2 ]
Seely, Andrew [4 ]
Sagar, Stephen [5 ,6 ]
Wong, Raimond [5 ,6 ]
Seely, Dugald [1 ]
机构
[1] Canadian Coll Naturopath Med, Dept Res & Epidemiol, Toronto, ON, Canada
[2] Univ Toronto, Leslie Dan Fac Pharm, Toronto, ON, Canada
[3] Univ Toronto, Lab Med & Pathobiol LMP, Toronto, ON, Canada
[4] Ottawa Hosp Res Inst, Dept Surg, Ottawa, ON, Canada
[5] McMaster Univ, Juravinski Canc Ctr, Hamilton, ON, Canada
[6] McMaster Univ, Dept Med, Hamilton, ON, Canada
基金
加拿大健康研究院;
关键词
GYNECOLOGIC RADIATION ONCOLOGY; A/J MOUSE LUNG; SODIUM SELENITE; PROSTATE-CANCER; METHYLSELENINIC ACID; ORGANOSELENIUM COMPOUND; NUTRITIONAL PREVENTION; DIETARY SUPPLEMENTATION; MELANOMA-CELLS; SOLID TUMORS;
D O I
10.1371/journal.pone.0026259
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
Background: Selenium is a natural health product widely used in the treatment and prevention of lung cancers, but large chemoprevention trials have yielded conflicting results. We conducted a systematic review of selenium for lung cancers, and assessed potential interactions with conventional therapies. Methods and Findings: Two independent reviewers searched six databases from inception to March 2009 for evidence pertaining to the safety and efficacy of selenium for lung cancers. Pubmed and EMBASE were searched to October 2009 for evidence on interactions with chemo- or radiation-therapy. In the efficacy analysis there were nine reports of five RCTs and two biomarker-based studies, 29 reports of 26 observational studies, and 41 preclinical studies. Fifteen human studies, one case report, and 36 preclinical studies were included in the interactions analysis. Based on available evidence, there appears to be a different chemopreventive effect dependent on baseline selenium status, such that selenium supplementation may reduce risk of lung cancers in populations with lower baseline selenium status (serum, <106 ng/mL), but increase risk of lung cancers in those with higher selenium (>= 121.6 ng/mL). Pooling data from two trials yielded no impact to odds of lung cancer, OR 0.93 (95% confidence interval 0.61-1.43); other cancers that were the primary endpoints of these trials, OR 1.51 (95%CI 0.70-3.24); and all-cause-death, OR 0.93 (95%CI 0.79-1.10). In the treatment of lung cancers, selenium may reduce cisplatin-induced nephrotoxicity and side effects associated with radiation therapy. Conclusions: Selenium may be effective for lung cancer prevention among individuals with lower selenium status, but at present should not be used as a general strategy for lung cancer prevention. Although promising, more evidence on the ability of selenium to reduce cisplatin and radiation therapy toxicity is required to ensure that therapeutic efficacy is maintained before any broad clinical recommendations can be made in this context.
引用
收藏
页数:10
相关论文
共 92 条
[1]
Chemical forms of selenium for cancer prevention [J].
Abdulah, R ;
Miyazaki, K ;
Nakazawa, M ;
Koyama, H .
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, 2005, 19 (2-3) :141-150
[2]
The revised CONSORT statement for reporting randomized trials: Explanation and elaboration [J].
Altman, DG ;
Schulz, KF ;
Moher, D ;
Egger, M ;
Davidoff, F ;
Elbourne, D ;
Gotzsche, PC ;
Lang, T .
ANNALS OF INTERNAL MEDICINE, 2001, 134 (08) :663-694
[3]
*AM CANC SOC, 2010, CANC REF INF WHAT AR
[4]
The impact of high-dose sodium selenite therapy on Bcl-2 expression in adult non-Hodgkin's lymphoma patients: Correlation with response and survival [J].
Asfour, Inas A. ;
Fayek, Manal ;
Raouf, Soha ;
Soliman, Marize ;
Hegab, Hany M. ;
El-Desoky, Hosam ;
Saleh, Rehab ;
Moussa, Mohamed A. R. .
BIOLOGICAL TRACE ELEMENT RESEARCH, 2007, 120 (1-3) :1-10
[5]
Methods of assessment of selenium status in humans: a systematic review [J].
Ashton, Kate ;
Hooper, Lee ;
Harvey, Linda J. ;
Hurst, Rachel ;
Casgrain, Amelie ;
Fairweather-Tait, Susan J. .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2009, 89 (06) :2025S-2039S
[6]
Silencing survivin results in synergy between methylseleninic acid and paclitaxel against skov3 ovarian cancer cells [J].
Azrak, Rami G. ;
Frank, Cheryl L. ;
Ghadersohi, Ali ;
Rustum, Youcef M. .
CANCER BIOLOGY & THERAPY, 2008, 7 (12) :1901-1908
[7]
BALDEW GS, 1989, CANCER RES, V49, P3020
[8]
Quality assessment of physical research in homeopathy [J].
Becker-Witt, C ;
Weisshuhn, TER ;
Lüdtke, R ;
Willich, SN .
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, 2003, 9 (01) :113-132
[9]
Selenium in the treatment of head and neck lymphedema [J].
Bruns, F ;
Büntzel, J ;
Mücke, R ;
Schönekaes, K ;
Kisters, K ;
Micke, O .
MEDICAL PRINCIPLES AND PRACTICE, 2004, 13 (04) :185-190
[10]
Büntzel J, 2006, TRACE ELEM ELECTROLY, V23, P178