Separation of the stereoisomers of racemic fluoroquinolone antibacterial agents on a crown-ether-based chiral HPLC stationary phase

被引：74

作者：

Hyun, MH ^{[1
]}

Han, SC

Jin, JS

Lee, W

机构：

[1] Pusan Natl Univ, Dept Chem, Pusan 609735, South Korea

[2] Pusan Natl Univ, Chem Inst Funct Mat, Pusan 609735, South Korea

[3] Forea Food & Drug Adm, Dept Drug Evaluat, Eunpyung Ku, Seoul 122704, South Korea

[4] LG Chem Ltd, Taejon 305380, South Korea

来源：

CHROMATOGRAPHIA | 2000年 / 52卷 / 7-8期

关键词：

column liquid chromatography; enantiomer separation; chiral stationary phase; chiral crown ether; quinolone antibacterial agents;

D O I：

10.1007/BF02535722

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A chiral stationary phase derived from (+)-( 18-crown-6)-2,3,11,12-tetracarboxylic acid has been successfully used for the direct separation of the enantiomers of racemic fluoroquinolines containing a primary amino group being investigated as antibacterial agents. The chromatographic resolution behavior was found to depend on the content and the type of acidic and organic modifiers in the mobile phase and on the column temperature.

引用

收藏

页码：473 / 476

页数：4

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