HLA-DR,DQ and APOE genotypes and gender influence in Sardinian primary progressive MS

被引：25

作者：

Cocco, E

Sotgiu, A

Costa, G

Murru, MR

Mancosu, C

Murru, R

Lai, M

Contu, P

Marrosu, MG

机构：

[1] Osped Binaghi, Ctr Sclerosi Multipla, Dipartimento Neurosci, I-09126 Cagliari, Italy

[2] Osped Binaghi, Ctr Sclerosi Multipla, Dipartimento Salute Pubblica, I-09126 Cagliari, Italy

来源：

NEUROLOGY | 2005年 / 64卷 / 03期

关键词：

D O I：

10.1212/01.WNL.0000150579.54878.00

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors examined the influence of APOE and human leukocyte antigen-DRB1-DQB1 polymorphisms on the course of multiple sclerosis in 871 patients, 773 with relapsing and 98 with primary progressive disease, and 348 control subjects. The risk of the primary progressive course was increased (odds ratio = 6.81, p = 0.002) in women carrying the APOE4 but not the DRB1-DQB1 predisposing genotype, suggesting in this subgroup of patients a reciprocal influence between these genes and gender in modulating clinical variability of the disease.

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收藏

页码：564 / 566

页数：3

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