Role of host lysosomal associated membrane protein (LAMP) in Trypanosoma cruzi invasion and intracellular development

被引：30

作者：

Albertti, L. A. G. ^{[1
]}

Macedo, A. M. ^{[2
]}

Chiari, E. ^{[3
]}

Andrews, N. W. ^{[4
]}

Andrade, L. O. ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Dept Morphol, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Dept Biochem & Immunol, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Dept Parasitol, BR-31270901 Belo Horizonte, MG, Brazil

[4] Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA

来源：

MICROBES AND INFECTION | 2010年 / 12卷 / 10期

基金：

美国国家卫生研究院;

关键词：

T; cruzi; Lysosomes; LAMP; Cell invasion; CELL INVASION; MAMMALIAN-CELLS; TRANS-SIALIDASE; FUSION; FORMS; EXOCYTOSIS; VACUOLE; ACID; PH;

D O I：

10.1016/j.micinf.2010.05.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Trypanosoma cruzi host cell entry depends on lysosomes for the formation of the parasitophorous vacuole. Lysosome internal surface is covered by two major proteins, highly sialilated, Lysosome Associated Membrane Proteins 1 and 2. T. cruzi, on the other hand, needs to acquire sialic acid from its host cell through the activity of trans-sialidase, an event that contributes to host cell invasion and later for parasite vacuole escape. Using LAMP1/2 knock out cells we were able to show that these two proteins are important for T. cruzi infection of host cells, both in entrance and intracellular development, conceivably by being the major source of sialic acid for T. cruzi. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：784 / 789

页数：6

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