Revised Estimates for the Number of Human and Bacteria Cells in the Body

被引：3956

作者：

Sender, Ron ^{[1
]}

Fuchs, Shai ^{[2
,3
,4
]}

Milo, Ron ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Plant & Environm Sci, Rehovot, Israel

[2] Weizmann Inst Sci, Dept Mol Genet, Rehovot, Israel

[3] Univ Toronto, Hosp Sick Children, Div Endocrinol, Toronto, ON, Canada

[4] Univ Toronto, Dept Pediat, Toronto, ON, Canada

来源：

PLOS BIOLOGY | 2016年 / 14卷 / 08期

基金：

欧洲研究理事会;

关键词：

IN-SITU HYBRIDIZATION; CELLULAR-LEVEL; NORMAL VALUES; CANCER-RISK; VOLUMES; VALIDATION; TRANSIT; WEIGHT; MODEL; MASS;

D O I：

10.1371/journal.pbio.1002533

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Reported values in the literature on the number of cells in the body differ by orders of magnitude and are very seldom supported by any measurements or calculations. Here, we integrate the most up-to-date information on the number of human and bacterial cells in the body. We estimate the total number of bacteria in the 70 kg "reference man" to be 3.8.10(13). For human cells, we identify the dominant role of the hematopoietic lineage to the total count (approximate to 90%) and revise past estimates to 3.0.10(13) human cells. Our analysis also updates the widely-cited 10:1 ratio, showing that the number of bacteria in the body is actually of the same order as the number of human cells, and their total mass is about 0.2 kg.

引用

页数：14

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