Poor predictive value of positive interim FDG-PET/CT in primary mediastinal large B-cell lymphoma

被引：32

作者：

Lazarovici, Julien ^{[1
]}

Terroir, Marie ^{[2
]}

Arfi-Rouche, Julia ^{[3
]}

Michot, Jean-Marie ^{[4
]}

Mussot, Sacha ^{[5
]}

Florea, Valentina ^{[5
]}

Ghigna, Maria-Rosa ^{[6
]}

Dartigues, Peggy ^{[7
]}

Petrovanu, Cynthia ^{[1
]}

Danu, Alina ^{[1
]}

Ferme, Christophe ^{[1
]}

Ribrag, Vincent ^{[1
]}

Ghez, David ^{[1
]}

机构：

[1] Gustave Roussy & Univ Paris Saclay, Dept Hematol, 114 Rue Edouard Vaillant, F-94805 Villejuif, France

[2] Gustave Roussy & Univ Paris Saclay, Dept Nucl Med & Endocrine Oncol, 114 Rue Edouard Vaillant, F-94805 Villejuif, France

[3] Gustave Roussy & Univ Paris Saclay, Dept Radiol, 114 Rue Edouard Valliant, F-94805 Villejuif, France

[4] Gustave Roussy & Univ Paris Saclay, Dept Drug Dev DITEP, 114 Rue Edouard Valliant, F-94805 Villejuif, France

[5] Marie Lannelongue Hosp, Dept Thorac Surg, 133 Ave Resistance, F-92350 Le Plessis Robinson, France

[6] Marie Lannelongue Hosp, Dept Pathol, 133 Ave Resistance, F-92350 Le Plessis Robinson, France

[7] Gustave Roussy & Univ Paris Saclay, Dept Pathol, 114 Rue Edouard Vaillant, F-94805 Villejuif, France

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2017年 / 44卷 / 12期

关键词：

18FDG pet/Ct; Primary mediastinal large B-cell lymphoma; Positive predictive value; POSITRON-EMISSION-TOMOGRAPHY; EVENT-FREE SURVIVAL; PROGNOSTIC VALUE; RESPONSE ASSESSMENT; F-18-FDG PET; SINGLE INSTITUTION; CYCLES; CHEMOTHERAPY; HODGKIN; CHOP;

D O I：

10.1007/s00259-017-3758-5

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

Purpose Though commonly used to assess response to therapy, the prognostic value of interim FDG-PET/CT in Primary Mediastinal Large B-cell Lymphoma (PMBCL) is unclear. Methods We conducted a retrospective study on 36 consecutive patients treated at our institution for a PMBCL between 2006 and 2014. All patients with a positive interim FDG-PET/CT had undergone histological restaging consisting either in a surgical debulking of the residual lesion (15 patients) or a CT-guided core needle biopsy (two patients). All FDG-PET/CT were secondarily reviewed according to the more recent Deauville criteria. Results Interim FDG-PET/CT was considered positive in 17/36 patients using visual evaluation. Among these patients, 14 had a Deauville score of 4. Histological restaging was negative in all but one case, showing inflammation and/or fibrosis. After a median follow-up of 48.5 months, a total of five patients have relapsed, two patients in the positive FDG-PET/CT group, and three patients in the negative FDG-PET/CT group, respectively. Conclusions These data indicate that a positive interim FDG-PET/CT does not reflect persistence of active disease in the vast majority of PMBCL cases. The relapse rate appears similar regardless of interim FDG-PET/CT results and interpretation criteria. This suggests that interim FDG-PET/CT has a poor positive predictive value, thus kt should be used with caution in PMBCL.

引用

页码：2018 / 2024

页数：7

共 34 条

[1]

Controversies on the prognostic value of interim FDG-PET in advanced-stage Hodgkin lymphoma [J].