Acyclovir-resistant varicella infection with atypical lesions in a non-HIV leukemic infant

被引：11

作者：

Crassard, N

Souillet, AL

Morfin, F

Thouvenot, D

Claudy, A

Bertrand, Y

机构：

[1] Hop Edward Herriot, Dept Dermatol, Lyon, France

[2] Hosp Civils Lyon, Virol Lab, Lyon, France

来源：

ACTA PAEDIATRICA | 2000年 / 89卷 / 12期

关键词：

D O I：

10.1080/080352500456732

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

An HIV-negative infant presented with VZV primary infection during the maintenance therapy for megakaryoblastic leukaemia. The lesions were initially vesicular and necrotic but became verrucous and hyperkeratotic. A clinical resistance to acyclovir was suspected and confirmed by histologic and virologic studies. The patient was successfully treated by foscarnet. Conclusion: resistance of VZV to acyclovir may occur after a short treatment in a non-AIDS patient.

引用

收藏

页码：1497 / 1499

页数：3

相关论文

共 16 条

[1]

BALFOUR HH, 1994, J ACQ IMMUN DEF SYND, V7, P254

[2] Sequential use of intravenous and oral acyclovir in the therapy of varicella in immunocompromised children [J].

Carcao, MD ;

Lau, RC ;

Gupta, A ;

Huerter, H ;

Koren, G ;

King, SM .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1998, 17 (07) :626-631

[3]

FELDMAN S, 1975, PEDIATRICS, V56, P388

[4]

FELDMAN S, 1987, PEDIATRICS, V80, P465

[5] FOSCARNET-RESISTANT MULTIDERMATOMAL ZOSTER IN A PATIENT WITH AIDS [J].

FILLET, AM ;

VISSE, B ;

CAUMES, E ;

DUMONT, B ;

GENTILINI, M ;

HURAUX, JM .

CLINICAL INFECTIOUS DISEASES, 1995, 21 (05) :1348-1349

[6] ACYCLOVIR-RESISTANT VARICELLA ZOSTER VIRUS-INFECTION AFTER CHRONIC ORAL ACYCLOVIR THERAPY IN PATIENTS WITH THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME (AIDS) [J].

JACOBSON, MA ;

BERGER, TG ;

FIKRIG, S ;

BECHERER, P ;

MOOHR, JW ;

STANAT, SC ;

BIRON, KK .

ANNALS OF INTERNAL MEDICINE, 1990, 112 (03) :187-191

[7]

Lesueur A, 1998, ANN DERMATOL VENER, V125, P127

[8] Phenotypic and genetic characterization of thymidine kinase from clinical strains of Varicella-Zoster virus resistant to acyclovir [J].

Morfin, F ;

Thouvenot, D ;

de Turenne-Tessier, M ;

Lina, B ;

Aymard, M ;

Ooka, T .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (10) :2412-2416

[9] CONTINUOUS VARICELLA-ZOSTER INFECTION ASSOCIATED WITH ACYCLOVIR RESISTANCE IN A CHILD WITH AIDS [J].

PAHWA, S ;

BIRON, K ;

LIM, W ;

SWENSON, P ;

KAPLAN, MH ;

SADICK, N ;

PAHWA, R .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1988, 260 (19) :2879-2882

[10] ACYCLOVIR THERAPY OF CHICKENPOX IN IMMUNOSUPPRESSED CHILDREN - A COLLABORATIVE STUDY [J].

PROBER, CG ;

KIRK, LE ;

KEENEY, RE .

JOURNAL OF PEDIATRICS, 1982, 101 (04) :622-625