Principles of chromosomal organization: lessons from yeast

被引：100

作者：

Zimmer, Christophe ^{[1
,4
]}

Fabre, Emmanuelle ^{[2
,3
,5
]}

机构：

[1] Inst Pasteur, Dept Biol Cellulaire & Infect, Grp Imagerie & Modelisat, F-75015 Paris, France

[2] Inst Pasteur, Dept Genomes & Genet, Unite Genet Mol Levures, F-75015 Paris, France

[3] Inst Pasteur, Dept Genomes & Genet, Lab Regulat Spatiale Fonct Genom, F-75015 Paris, France

[4] CNRS, URA 2582, F-75015 Paris, France

[5] CNRS, URA 2171, F-75015 Paris, France

来源：

JOURNAL OF CELL BIOLOGY | 2011年 / 192卷 / 05期

关键词：

DOUBLE-STRAND BREAKS; SACCHAROMYCES-CEREVISIAE TELOMERES; NUCLEAR-PORE COMPLEX; DOMAIN PROTEIN MPS3; TRANSFER-RNA GENES; SPINDLE POLE BODY; ASSEMBLY FACTOR-I; BUDDING YEAST; CHROMATIN FIBER; LINKER HISTONE;

D O I：

10.1083/jcb.201010058

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

-The spatial organization of genes and chromosomes plays an important role in the regulation of several DNA processes. However, the principles and forces underlying this nonrandom organization are mostly unknown. Despite its small dimension, and thanks to new imaging and biochemical techniques, studies of the budding yeast nucleus have led to significant insights into chromosome arrangement and dynamics. The dynamic organization of the yeast genome during interphase argues for both the physical properties of the chromatin fiber and specific molecular interactions as drivers of nuclear order.

引用

页码：723 / 733

页数：11

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