Epstein-Barr virus small RNA (EBER) genes:: Differential regulation during lytic viral replication

被引：35

作者：

Greifenegger, N

Jäger, M

Kunz-Scughart, LA

Wolf, H

Schwarzmann, F

机构：

[1] Univ Regensburg, Inst Med Mikrobiol & Hyg, D-93053 Regensburg, Germany

[2] Univ Regensburg, Inst Pathol, D-93053 Regensburg, Germany

来源：

JOURNAL OF VIROLOGY | 1998年 / 72卷 / 11期

关键词：

D O I：

10.1128/JVI.72.11.9323-9328.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In every latently Epstein-Barr virus-infected cell the viral genes EBER-1 and EBER-2 are transcribed by polymerase III, In lytically infected cells in vivo the EBER genes could not be detected. However, in cell culture downregulation could not be confirmed, and hence the relevance of this shutdown to the replication of the virus was not clear. We assayed the transcriptional activity of the EBER genes by nuclear run-on assays with enriched lytically infected cells and demonstrated that EBER-1 and EBER-2 are differentially downregulated on the transcriptional level during the switch to lytic viral replication. This downregulation was an early event during the lytic replication of the virus.

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页码：9323 / 9328

页数：6

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