Expression profiles. of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements

被引:64
作者
Rozovskaia, T
Ravid-Amir, O
Tillib, S
Getz, G
Feinstein, E
Agrawal, H
Nagler, A
Rappaport, EF
Issaeva, I
Matsuo, Y
Kees, UR
Lapidot, T
Lo Coco, F
Foa, R
Mazo, A
Nakamura, T
Croce, CM [1 ]
Cimino, G
Domany, E
Canaani, E
机构
[1] Weizmann Inst Sci, Dept Phys Complex Syst, IL-76100 Rehovot, Israel
[2] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel
[3] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel
[4] Jefferson Med Coll, Kimmel Canc Ctr, Philadelphia, PA 19107 USA
[5] Russian Acad Sci, Inst Gene Biol, Moscow 119334, Russia
[6] Quark Biotech Inc, Cleveland, OH 44106 USA
[7] Sheba Med Ctr, IL-52621 Tel Hashomer, Israel
[8] Childrens Hosp, Philadelphia, PA 19104 USA
[9] Fujisaki Cell Ctr, Okayama 7028006, Japan
[10] Inst Child Hlth Res, Subiaco, WA 6008, Australia
[11] Univ Roma La Sapienza, Dept Cellular Biotechnol & Hematol, I-00161 Rome, Italy
关键词
D O I
10.1073/pnas.1132115100
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The ALL-1 gene is directly involved in 5-10% of acute lymphoblastic leukemias (ALLs) and acute myeloid leukemias (AMLs) by fusion to other genes or through internal rearrangements. DNA microarrays were used to determine expression profiles of ALLs and AMLs with ALL-1 rearrangements. These profiles distinguish those tumors from other ALLs and AMLs. The expression patterns of ALL-1-associated tumors, in particular ALLs, involve oncogenes, tumor suppressors, antiapoptotic genes, drug-resistance genes, etc., and correlate with the aggressive nature of the tumors. The genes whose expression differentiates between ALLs with and without ALL-1 rearrangement were further divided into several groups, enabling separation of ALL-1-associated ALLs into two subclasses. One of the groups included 43 genes that exhibited expression profiles closely linked to ALLs with ALL-1 rearrangements. Further, there were evident differences between the expression profiles of AMLs in which ALL-1 had undergone fusion to other genes and AMLs with partial duplication of ALL-1. The extensive analysis described here pinpointed genes that might have a direct role in pathogenesis.
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页码:7853 / 7858
页数:6
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