Neurogenesis in the aging brain

被引：112

作者：

Apple, Deana M.

Solano-Fonseca, Rene

Kokovay, Erzsebet ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Cell Syst & Anat, San Antonio, TX 78229 USA

来源：

BIOCHEMICAL PHARMACOLOGY | 2017年 / 141卷

关键词：

Neurogenesis; Neural stem cells; Niche; Aging; Interventions; NEURAL STEM-CELLS; ADULT SUBVENTRICULAR ZONE; PROGENITOR CELLS; HIPPOCAMPAL NEUROGENESIS; DIETARY RESTRICTION; CALORIE RESTRICTION; VASCULAR NICHE; DENTATE GYRUS; FOREBRAIN NEUROGENESIS; NEUROTROPHIC FACTOR;

D O I：

10.1016/j.bcp.2017.06.116

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Adult neurogenesis is the process of producing new neurons from neural stem cells (NSCs) for integration into the brain circuitry. Neurogenesis occurs throughout life in the ventricular-subventricular zone (VSVZ) of the lateral ventricle and the subgranular zone (SGZ) of the hippocampal dentate gyrus. However, during aging, NSCs and their progenitors exhibit reduced proliferation and neuron production, which is thought to contribute to age-related cognitive impairment and reduced plasticity that is necessary for some types of brain repair. In this review, we describe NSCs and their niches during tissue homeostasis and how they undergo age-associated remodeling and dysfunction. We also discuss some of the functional ramifications in the brain from NSC aging. Finally, we discuss some recent insights from interventions in NSC aging that could eventually translate into therapies for healthy brain aging. (c) 2017 Elsevier Inc. All rights reserved.

引用

页码：77 / 85

页数：9

共 128 条

[1]

Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss [J].