The Mnx homeobox gene class defined by HB9, MNR2 and amphioxus AmphiMnx

被引：46

作者：

Ferrier, DEK

Brooke, NM

Panopoulou, G

Holland, PWH

机构：

[1] Univ Reading, Sch Anim & Microbial Sci, Reading RG6 6AJ, Berks, England

[2] Max Planck Inst Mol Genet, D-14195 Berlin, Germany

来源：

DEVELOPMENT GENES AND EVOLUTION | 2001年 / 211卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

homeobox; motor neuron; amphioxus; gene duplication;

D O I：

10.1007/s004270000124

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The HB9 homeobox gene has been cloned from several vertebrates and is implicated in motor neuron differentiation. In the chick, a related gene, MNR2, acts upstream of HB9 in this process. Here we report an amphioxus homologue of these genes and show that it diverged before the gene duplication yielding HB9 and MNR2. AmphiMnx RNA is detected in two irregular punctate stripes along the developing neural tube, comparable to the distribution of 'dorsal compartment' motor neurons, and also in dorsal endoderm and posterior mesoderm. We propose a new homeobox class, Mnx, to include AmphiMnx, HB9, MNR2 and their Drosophila and echinoderm orthologues; we suggest that vertebrate HB9 is renamed Mnx1 and MNR2 be renamed Mnx2.

引用

页码：103 / 107

页数：5

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