Munc18=1 in secretion: lonely Munc joins SNARE team and takes control

被引：150

作者：

Toonen, Ruud F. G.

Verhage, Matthijs ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Ctr Neurogenom & Cognit Res, Dept Functional Genom, NL-1081 HV Amsterdam, Netherlands

[2] Vrije Univ Amsterdam Med Ctr, NL-1081 HV Amsterdam, Netherlands

来源：

TRENDS IN NEUROSCIENCES | 2007年 / 30卷 / 11期

关键词：

D O I：

10.1016/j.tins.2007.08.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

SNARE proteins and the Sec1/Munc18 (SM) protein, Munc18-11, are essential components of the mammalian secretion machinery. Until recently, quite divergent working models existed for the central but rather isolated role of Munc18-11 in secretion and its relation to the SNAREs. New studies now solve old discrepancies, bring consensus among SM-SNARE interactions and emphasize how closely these proteins work together. Together, SM and SNARE proteins control each step in the exocytotic pathway as a team. Munc18-1 operates as the chief commander of the exocytotic SNARE team, making teamwork more efficient, working with specific team members on specific jobs, reducing promiscuity with members of noncognate teams, and adjusting team efforts as a function of recent history and environmental cues (presynaptic receptor activation).

引用

页码：564 / 572

页数：9

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