Synthesis of (-)-(3S)-1-(3-aminopropyl)-3-methylazacyclodecane, the structure proposed for the marine alkaloid haliclorensin

被引：23

作者：

Heinrich, MR ^{[1
]}

Steglich, W ^{[1
]}

机构：

[1] Univ Munich, Dept Chem, D-81377 Munich, Germany

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 19期

关键词：

haliclorensin; alkaloids; marine metabolites; sponges; synthesis; metathesis;

D O I：

10.1016/S0040-4039(01)00435-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of both enantiomers of the title compound has been achieved in seven steps with 19% overall yield. The synthetic diamine differs in its NMR data and optical rotation from haliclorensin, a marine alkaloid for which the same structure had been proposed. (C) 2001 Published by Elsevier Science Ltd.

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页码：3287 / 3289

页数：3

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