Impact of mindfulness-based stress reduction training on intrinsic brain connectivity

被引:217
作者
Kilpatrick, Lisa A. [1 ,3 ]
Suyenobu, Brandall Y. [1 ,3 ]
Smith, Suzanne R. [1 ,3 ]
Bueller, Joshua A. [1 ,3 ]
Goodman, Trudy [7 ]
Creswell, J. David [6 ]
Tillisch, Kirsten [1 ,3 ]
Mayer, Emeran A. [1 ,3 ,4 ]
Naliboff, Bruce D. [1 ,2 ,5 ]
机构
[1] Univ Calif Los Angeles, Ctr Neurobiol Stress, David Geffen Sch Med, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, David Geffen Sch Med, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Dept Med, David Geffen Sch Med, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, David Geffen Sch Med, Brain Res Inst, Los Angeles, CA 90095 USA
[5] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA
[6] Carnegie Mellon Univ, LA, Los Angeles, CA USA
[7] LA, Insight, Los Angeles, CA USA
基金
美国国家卫生研究院;
关键词
Mindfulness; Meditation; Functional connectivity; Resting state fMRI; Auditory; Attention; STATE FUNCTIONAL CONNECTIVITY; HUMAN VISUAL-CORTEX; PREFRONTAL CORTEX; NETWORKS; FMRI; FLUCTUATIONS; ORGANIZATION; MODULATION; ATTENTION; CINGULATE;
D O I
10.1016/j.neuroimage.2011.02.034
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The beneficial effects of mindful awareness and mindfulness meditation training on physical and psychological health are thought to be mediated in part through changes in underlying brain processes. Functional connectivity MRI (fcMRI) allows identification of functional networks in the brain. It has been used to examine state-dependent activity and is well suited for studying states such as meditation. We applied fcMRI to determine if Mindfulness-Based Stress Reduction (MBSR) training is effective in altering intrinsic connectivity networks (ICNs). Healthy women were randomly assigned to participate in an 8-week Mindfulness-Based Stress Reduction (MBSR) training course or an 8-week waiting period. After 8 weeks, fMRI data (1.5 T) was acquired while subjects rested with eyes closed, with the instruction to pay attention to the sounds of the scanner environment. Group independent component analysis was performed to investigate training-related changes in functional connectivity. Significant MBSR-related differences in functional connectivity were found mainly in auditory/salience and medial visual networks. Relative to findings in the control group, MBSR subjects showed (1) increased functional connectivity within auditory and visual networks, (2) increased functional connectivity between auditory cortex and areas associated with attentional and self-referential processes, (3) stronger anticorrelation between auditory and visual cortex, and (4) stronger anticorrelation between visual cortex and areas associated with attentional and self-referential processes. These findings suggest that 8 weeks of mindfulness meditation training alters intrinsic functional connectivity in ways that may reflect a more consistent attentional focus, enhanced sensory processing, and reflective awareness of sensory experience. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:290 / 298
页数:9
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