Nuclear factor kappa B role in inflammation associated gastrointestinal malignancies

被引：142

作者：

Gambhir, Sahil ^{[1
]}

Vyas, Dinesh ^{[1
]}

Hollis, Michael ^{[1
]}

Aekka, Apporva ^{[1
]}

Vyas, Arpita ^{[2
]}

机构：

[1] Michigan State Univ, Dept Surg, Coll Human Med, E Lansing, MI 48912 USA

[2] Michigan State Univ, Dept Pediat, Coll Human Med, E Lansing, MI 48912 USA

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2015年 / 21卷 / 11期

关键词：

Gastrointestinal cancer; Inflammation; Nuclear factor kappa B; GASTRIC-CANCER CELLS; RELA TRANSCRIPTION FACTOR; COLITIS-ASSOCIATED CANCER; HUMAN COLORECTAL-CANCER; HELICOBACTER-PYLORI; EPITHELIAL-CELLS; SIGNALING PATHWAY; NEOADJUVANT CHEMORADIOTHERAPY; CHEMORADIATION RESISTANCE; ESOPHAGEAL ADENOCARCINOMA;

D O I：

10.3748/wjg.v21.i11.3174

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Nuclear factor kappa B (NF-kappa B) has an established role in the regulation of innate immunity and inflammation. NF-kappa B is also involved in critical mechanisms connecting inflammation and cancer development. Recent investigations suggest that the NF-kappa B signaling cascade may be the central mediator of gastrointestinal malignancies including esophageal, gastric and colorectal cancers. This review will explore NF-kappa B's function in inflammation-associated gastrointestinal malignancies, highlighting its oncogenic contribution to each step of carcinogenesis. NF-kappa B's role in the inflammation-to-carcinoma sequence in gastrointestinal malignancies warrants stronger emphasis upon targeting this pathway in achieving greater therapeutic efficacy.

引用

页码：3174 / 3183

页数：10

共 89 条

[1]

NF-κB activation in Esophageal adenocarcinoma -: Relationship to Barrett's metaplasia, survival, and response to neoadjuvant chemoradiotherapy [J].