Source of endothelin-1 in subarachnoid hemorrhage

被引：16

作者：

Bertsch, T

Kuehl, S

Muehlhauser, F

Walter, S

Hodapp, B

Rossol, S

Schmeck, J

Ragoschke, A

Schütt, S

Fritzinger, M

Horn, P

Vajkoczy, P

Wendel-Wellner, M

Fassbender, K

机构：

[1] Heidelberg Univ, Clin Mannheim, Dept Neurol, D-68135 Mannheim, Germany

[2] Heidelberg Univ, Clin Mannheim, Dept Clin Chem, D-68135 Mannheim, Germany

[3] Heidelberg Univ, Clin Mannheim, Dept Internal Med, D-68135 Mannheim, Germany

[4] Heidelberg Univ, Clin Mannheim, Dept Anesthesiol, D-68135 Mannheim, Germany

[5] Heidelberg Univ, Clin Mannheim, Dept Neurosurg, D-68135 Mannheim, Germany

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2001年 / 39卷 / 04期

关键词：

subarachnoidal hemorrhage; endothelin-1; vasospasm; cerebral ischemia;

D O I：

10.1515/CCLM.2001.053

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Endothelin-1 is the most potent vasoconstrictor known to date. This peptide is believed to play a pathophysiological role in the development of vasospasm, the most important complication of subarachnoid hemorrhage (SAH). In the present study we investigated the release of endothelin-1 in SAH and analyzed the cellular source of this peptide. At a protein and mRNA level we were able to show that endothelin-1 is produced by mononuclear leukocytes. Complementary in vitro studies revealed that aging and subsequent hemolysis of blood is sufficient to induce production of endothelin-1 by mononuclear leukocytes. Thus, cerebrospinal fluid-derived mononuclear leukocytes are a source of endothelin-1 in patients suffering from SAH. This finding may have important therapeutic implications as anti-leukocyte strategies could prevent cerebrovascular complications in SAH patients.

引用

页码：341 / 345

页数：5

共 33 条

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