Alcohol and the cardiovascular system - Research challenges and opportunities

被引:128
作者
Lucas, DL
Brown, RA
Wassef, M
Giles, TD
机构
[1] Louisiana State Univ, Sch Med, Hlth Sci Ctr, Cardiovasc Res Sect,Dept Med, New Orleans, LA 70112 USA
[2] NIAAA, Div Metab & Hlth Effect, Bethesda, MD USA
[3] NHLBI, Div Heart & Vasc Dis, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1016/j.jacc.2005.02.075
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Excessive alcohol consumption has long been associated with cardiovascular disorders, including cardiomyopathy, hypertension, coronary artery disease, and stroke. However, recent evidence suggests that moderate alcohol intake can actually provide a measure of cardioprotection, particularly against coronary heart disease and ischemia-reperfusion injury. To explore the various dimensions of these opposing actions of alcohol, the National Institute on Alcohol Abuse and Alcoholism and the National Heart, Lung, and Blood Institute sponsored a state-of-the-art workshop on "Alcohol and the Cardiovascular System: Research Challenges and Opportunities" in Bethesda, Maryland, in May 2003. Speakers discussed the following topics: the epidemiology of alcohol and cardiovascular disease, clinical manifestations of alcohol, genetics of alcohol and cardiovascular disease, mechanisms underlying the molecular and cellular effects of alcohol, the application of new and emerging technology, and translation from discovery to therapeutic modalities of treatment. The panel concluded that future studies are needed to: 1) determine the role of genes and the environment in assessing mechanisms underlying the benefits of alcohol use and cardiovascular disease risk; 2) define the biological mechanisms underlying alcohol-induced peripheral vascular damage; 3) clarify the role of genetic variation in alcohol-metabolizing enzymes, genetic susceptibility, and pharmacogenomics in determining cardiovascular disease risk and effective treatment; 4) determine common mechanisms underlying alcohol-induced cardiovascular disease, such as oxidative stress and inflammation; 5) assess the role of insulin resistance, blood clotting, protein kinase C isoforms, and signal transduction mechanisms mediating alcohol's beneficial effects; and 6) explore the potential of stem cells in myocardial regeneration and repair in hearts damaged by alcohol. (c) 2005 by the American College of Cardiology Foundation.
引用
收藏
页码:1916 / 1924
页数:9
相关论文
共 51 条
[1]   Short-term acetaldehyde exposure depresses. ventricular myocyte contraction: Role of cytochrome P450 oxidase, xanthine oxidase, and lipid peroxidation [J].
Aberle, NS ;
Ren, J .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2003, 27 (04) :577-583
[2]   Alcohol consumption and prognosis in patients with left ventricular systolic dysfunction after a myocardial infarction [J].
Aguilar, D ;
Skali, H ;
Moyé, LA ;
Lewis, EF ;
Gaziano, JM ;
Rutherford, JD ;
Hartley, LH ;
Randall, OS ;
Geltman, EM ;
Lamas, GA ;
Rouleau, JL ;
Pfeffer, MA ;
Solomon, SD .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 43 (11) :2015-2021
[3]  
*AM HEART ASS, 2003, HEART DIS STROK STAT
[4]   HDL cholesterol and protective factors in atherosclerosis [J].
Assmann, G ;
Gotto, AM .
CIRCULATION, 2004, 109 (23) :8-14
[5]   Evidence that human cardiac myocytes divide after myocardial infarction (Publication with Expression of Concern. See vol. 379, pg. 1870, 2018) [J].
Beltrami, AP ;
Urbanek, K ;
Kajstura, J ;
Yan, SM ;
Finato, N ;
Bussani, R ;
Nadal-Ginard, B ;
Silvestri, F ;
Leri, A ;
Beltrami, CA ;
Anversa, P .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (23) :1750-1757
[6]  
Corti R, 2001, ANN NY ACAD SCI, V947, P181
[7]   Prevention and treatment of hypertension study (PATHS): effects of an alcohol treatment program on blood pressure [J].
Cushman, WC ;
Cutler, JA ;
Hanna, E ;
Bingham, SF ;
Follmann, D ;
Harford, T ;
Dubbert, P ;
Allender, PS ;
Dufour, M ;
Collins, JF ;
Walsh, SM ;
Kirk, GF ;
Burg, M ;
Felicetta, JV ;
Hamilton, BP ;
Katz, LA ;
Perry, HM ;
Willenberg, ML ;
Lakshman, R ;
Hamburger, RJ .
ARCHIVES OF INTERNAL MEDICINE, 1998, 158 (11) :1197-1207
[8]   Long-term alcohol consumption and the risk of atrial fibrillation in the Framingham Study [J].
Djoussé, L ;
Levy, D ;
Benjamin, EJ ;
Blease, SJ ;
Russ, A ;
Larson, MG ;
Massaro, JM ;
D'Agostino, RB ;
Wolf, PA ;
Ellison, RC .
AMERICAN JOURNAL OF CARDIOLOGY, 2004, 93 (06) :710-713
[9]   Alcohol consumption and risk of ischemic stroke -: The Framingham Study [J].
Djoussé, L ;
Ellison, RC ;
Beiser, A ;
Scaramucci, A ;
D'Agostino, RB ;
Wolf, PA .
STROKE, 2002, 33 (04) :907-912
[10]   Paraoxonase and atherosclerosis [J].
Durrington, PN ;
Mackness, B ;
Mackness, MI .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2001, 21 (04) :473-480