The success and failure of BCG - implications for a novel tuberculosis vaccine

被引：607

作者：

Andersen, P ^{[1
]}

Doherty, TM ^{[1
]}

机构：

[1] Statens Serum Inst, Dept Infect Dis Immunol, DK-2300 Copenhagen, Denmark

来源：

NATURE REVIEWS MICROBIOLOGY | 2005年 / 3卷 / 08期

关键词：

D O I：

10.1038/nrmicro1211

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

Over the past 50 years, the Mycobacterium bovis bacille Calmette Guerin ( BCG) vaccine against tuberculosis ( TB) has maintained its position as the world's most widely used vaccine, despite showing highly variable efficacy ( 0 - 80%) in different trials. The efficacy of BCG in adults is particularly poor in tropical and subtropical regions. Studies in animal models of TB, supported by data from clinical BCG trials in humans, indicate that this failure is related to pre-existing immune responses to antigens that are common to environmental mycobacteria and Mycobacterium tuberculosis. Here, we discuss the potential mechanisms behind the variation of BCG efficacy and their implications for an improved TB vaccination strategy.

引用

页码：656 / 662

页数：7

共 92 条

[1]

DOES THE PROTECTIVE EFFECT OF NEONATAL BCG CORRELATE WITH VACCINE-INDUCED TUBERCULIN REACTION [J].

ALKASSIMI, FA ;

ALHAJJAJ, MS ;

ALORAINEY, IO ;

BAMGBOYE, EA .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1995, 152 (05) :1575-1578

[2]

Long-term efficacy of BCG vaccine in American Indians and Alaska natives - A 60-year follow-up study [J].

Aronson, NE ;

Santosham, M ;

Comstock, GW ;

Howard, RS ;

Moulton, LH ;

Rhoades, ER ;

Harrison, LH .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 291 (17) :2086-2091

[3]

Baily G V, 1980, Indian J Med Res, V72 Suppl, P1

[4]

Has BCG attenuated to impotence? [J].

Behr, MA ;

Small, PM .

NATURE, 1997, 389 (6647) :133-134

[5]

Correlation between BCG genomics and protective efficacy [J].

Behr, MA .

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2001, 33 (04) :249-252

[6]

BCG-induced increase in interferon-gamma response to mycobacterial antigens and efficacy of BCG vaccination in Malawi and the UK: two randomised controlled studies [J].

Black, GF ;

Weir, RE ;

Floyd, S ;

Bliss, L ;

Warndorff, DK ;

Crampin, AC ;

Ngwira, B ;

Sichali, L ;

Nazareth, B ;

Blackwell, JM ;

Branson, K ;

Chaguluka, SD ;

Donovan, L ;

Jarman, E ;

King, E ;

Fine, PEM ;

Dockrell, HM .

LANCET, 2002, 359 (9315) :1393-1401

[7]

Patterns and implications of naturally acquired immune responses to environmental and tuberculous mycobacterial antigens in northern Malawi [J].

Black, GF ;

Dockrell, HM ;

Crampin, AC ;

Floyd, S ;

Weir, RE ;

Bliss, L ;

Sichali, L ;

Mwaungulu, L ;

Kanyongoloka, H ;

Ngwira, B ;

Warndorff, DK ;

Fine, PEM .

JOURNAL OF INFECTIOUS DISEASES, 2001, 184 (03) :322-329

[8]

Black GF, 2001, INT J TUBERC LUNG D, V5, P664

[9]

The protective effect of the Mycobacterium bovis BCG vaccine is increased by coadministration with the Mycobacterium tuberculosis 72-kilodalton fusion polyprotein Mtb72F in M-tuberculosis-infected guinea pigs [J].

Brandt, L ;

Skeiky, YAW ;

Alderson, MR ;

Lobet, Y ;

Dalemans, W ;

Turner, OC ;

Basaraba, RJ ;

Izzo, AA ;

Lasco, TM ;

Chapman, PL ;

Reed, SG ;

Orme, IM .

INFECTION AND IMMUNITY, 2004, 72 (11) :6622-6632

[10]

Failure of the Mycobacterium bovis BCG vaccine:: Some species of environmental mycobacteria block multiplication of BCG and induction of protective immunity to tuberculosis [J].

Brandt, L ;

Cunha, JF ;

Olsen, AW ;

Chilima, B ;

Hirsch, P ;

Appelberg, R ;

Andersen, P .

INFECTION AND IMMUNITY, 2002, 70 (02) :672-678

← 1 2 3 4 5 6 7 8 9 10 →