Focal segmental glomerulosclerosis: recent advances

被引：41

作者：

Pollak, Martin R. ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2008年 / 17卷 / 02期

关键词：

focal segmental glomerulosclerosis; glomerulus; nephrotic syndrome; podocyte;

D O I：

10.1097/MNH.0b013e3282f5dbe4

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Purpose of review Focal segmental glomerulosclerosis is a significant and growing cause of chronic kidney disease and nephrotic syndrome in adults and children. Recent findings The last year has seen continued progress in understanding podocyte biology, mechanisms of podocyte dysfunction, and its contribution to proteinuria and focal segmental glomerulosclerosis. Summary A number of studies have helped to elucidate the mechanisms of slit-diaphragm-mediated signaling to the podocyte cytoskeleton. Advances in treatment continue to lag behind advances in understanding focal segmental glomerulosclerosis disease biology.

引用

页码：138 / 142

页数：5

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