ASPREE-D: Aspirin for the prevention of depression in the elderly

被引：23

作者：

Berk, Michael ^{[1
,2
,3
,4
]}

Woods, R. L. ^{[2
]}

Nelson, M. R. ^{[5
]}

Shah, R. C. ^{[6
,7
]}

Reid, C. M. ^{[2
,8
]}

Storey, E. ^{[9
]}

Fitzgerald, S. M. ^{[2
]}

Lockery, J. E. ^{[2
]}

Wolfe, R. ^{[2
]}

Mohebbi, M. ^{[1
]}

Murray, A. M. ^{[10
]}

Kirpach, B. ^{[10
]}

Grimm, R. ^{[10
]}

McNeil, J. J. ^{[2
]}

机构：

[1] Deakin Univ, IMPACT Strateg Res Ctr, Sch Med, Barwon Hlth, Geelong, Vic, Australia

[2] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia

[3] Univ Melbourne, Dept Psychiat, Parkville, Vic, Australia

[4] Orygen Youth Hlth Res Ctr, Parkville, Vic, Australia

[5] Univ Tasmania, Menzies Inst Med Res, Hobart, Tas 7001, Australia

[6] Rush Univ, Med Ctr, Dept Family Med, Chicago, IL 60612 USA

[7] Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA

[8] Curtin Univ, Sch Publ Hlth, Perth, WA, Australia

[9] Monash Univ, Cent Clin Sch, Clayton, Vic 3800, Australia

[10] Hennepin Cty Med Ctr, Berman Ctr Outcomes & Clin Res, Minneapolis, MN 55415 USA

来源：

INTERNATIONAL PSYCHOGERIATRICS | 2016年 / 28卷 / 10期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会; 美国国家卫生研究院;

关键词：

immunology; antidepressants; biomarkers; aspirin; inflammation; risk; prevention; depression; C-REACTIVE PROTEIN; SCALE CES-D; ACETYLSALICYLIC-ACID; MAJOR DEPRESSION; INFLAMMATORY MARKERS; DISORDERS; AUGMENTATION; METAANALYSIS; ASSOCIATION; FLUOXETINE;

D O I：

10.1017/S104161021600079X

中图分类号：

B849 [应用心理学];

学科分类号：

040203 [应用心理学];

摘要：

Background: Not only is depression associated with increased inflammation but inflammation is a risk factor for the genesis of depression. Many of the environmental risk factors for depression are transduced through inflammatory signaling. Anti-inflammatory agents show promise for the management of depression in preclinical, epidemiological, and early clinical studies. This opens the door to the potential for anti-inflammatory agents to treat and prevent depression. There are no evidence-based pharmacotherapies for depression prevention. Method: ASPREE-D, aspirin in the prevention of depression in the elderly, is a sub study of ASPREE, which explores the potential of aspirin to prevent a range of inflammation related disorders in the elderly. With a sample size of 19,114, and a duration of 5 years, this placebo controlled study will be one of the largest randomized controlled trials in psychiatry and will provide definitive evidence on the ability of aspirin to prevent depression. Results: This paper presents the rationale for the study and presents a summary of the study design. Conclusions: ASPREE-D may not only define novel therapy but will provide mechanistic proof of concept of the role of inflammation in depression.

引用

页码：1741 / 1748

页数：8

共 28 条

[1]

Depression in the elderly [J].