Magnetic resonance spectroscopy facilitates assessment of intramyocellular lipid changes: a preliminary short-term study following biliopancreatic diversion

被引：13

作者：

Adami, GF ^{[1
]}

Parodi, RC ^{[1
]}

Papadia, F ^{[1
]}

Marinari, G ^{[1
]}

Camerini, G ^{[1
]}

Corvisieri, R ^{[1
]}

Scopinaro, N ^{[1
]}

机构：

[1] Univ Genoa, Dipartimento Discipline Chirurg, Fac Med, I-16132 Genoa, Italy

来源：

OBESITY SURGERY | 2005年 / 15卷 / 09期

关键词：

morbid obesity; bariatric surgery; insulin resistance; muscular fat; biliopancreatic diversion;

D O I：

10.1381/096089205774512483

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: Intramyocellular content of lipid (IMCL) appears to be important in the pathogenesis of insulin resistance, and the improvement of insulin activity observed following biliopancreatic diversion (BPD) for obesity has to be related to reduction of IMCL. This study evaluates the possibility of detecting changes after BPD in IMCL by means of H-1 magnetic resonance spectroscopy. Methods: The investigation was carried out in obese patients undergoing BPD prior to and at 1 month following the operation. Insulin sensitivity was assessed according to the homeostatic model of assessment (HOMA), and IMCL was determined by the spectroscopy of the tibialis anterior muscle. Results: At 1 month following BPD, an improvement in insulin action was observed in all subjects, and in nearly all cases the IMCL signal decreased. Conclusion: The data from this study indicate that magnetic resonance spectroscopy can detect IMCL changes following BPD and is fully suitable for longitudinal studies on muscle metabolic status.

引用

页码：1233 / 1237

页数：5

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