Basic biology and therapeutic implications of lncRNA

被引：283

作者：

Khorkova, O. ^{[1
]}

Hsiao, J. ^{[1
]}

Wahlestedt, C. ^{[2
,3
]}

机构：

[1] OPKO Hlth Inc, Miramar, FL 33025 USA

[2] Univ Miami, Miller Sch Med, Ctr Therapeut Innovat, Miami, FL 33136 USA

[3] Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, Miami, FL 33136 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2015年 / 87卷

关键词：

Natural antisense transcripts; lincRNA; vlincRNA; Telomeres; Paraspeckles; Imprinting; Epigenetic regulation; AntagoNAT; LONG NONCODING RNA; MESSENGER-RNA; GENE-EXPRESSION; TRANSCRIPTION; TERRA; LANDSCAPE; EVOLUTION; ELEMENTS; COMPLEX; NCRNA;

D O I：

10.1016/j.addr.2015.05.012

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Long non-coding RNAs (lncRNA), a class of non-coding RNA molecules recently identified largely due to the efforts of FANTOM, and later GENCODE and ENCODE consortia, have been a subject of intense investigation in the past decade. Extensive efforts to get deeper understanding of lncRNA biology have yielded evidence of their diverse structural and regulatory roles in protecting chromosome integrity, maintaining genomic architecture, X chromosome inactivation, imprinting, transcription, translation and epigenetic regulation. Here we will briefly review the recent studies in the field of lncRNA biology focusing mostly on mammalian species and discuss their therapeutic implications. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：15 / 24

页数：10

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