Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women

被引：317

作者：

van der Steeg, Jan Willem ^{[1
,2
,4
]}

Steures, Pieternel ^{[1
,2
,4
]}

Eijkemans, Marinus J. C. ^{[2
]}

Habbema, J. Dik F. ^{[2
]}

Hompes, Peter G. A. ^{[4
]}

Burggraaff, Jan M. ^{[5
]}

Oosterhuis, G. Jur E. ^{[6
]}

Bossuyt, Patrick M. M. ^{[3
]}

van der Veen, Fulco ^{[1
]}

Mol, Ben W. J. ^{[1
,7
]}

机构：

[1] Acad Med Ctr, Ctr Reprod Med, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Med Ctr Rotterdam, Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol & Biostat, NL-1105 AZ Amsterdam, Netherlands

[4] Vrije Univ Amsterdam, Med Ctr, Dept Obstet & Gynaecol, Amsterdam, Netherlands

[5] Scheperziekenhuis Emmen, Dept Obstet & Gynaecol, Emmen, Netherlands

[6] Med Spectrum Twente, Dept Obstet & Gynaecol, Enschede, Netherlands

[7] Maxima Med Ctr, Dept Obstet & Gynaecol, Veldhoven, Netherlands

来源：

HUMAN REPRODUCTION | 2008年 / 23卷 / 02期

关键词：

obesity; subfertility; pregnancy chance; spontaneous conception;

D O I：

10.1093/humrep/dem371

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Background: Obesity is increasing rapidly among women all over the world. Obesity is a known risk factor for subfertility due to anovulation, but it is unknown whether obesity also affects spontaneous pregnancy chances in subfertile, ovulatory women. Methods: We evaluated whether obesity affected the chance of a spontaneous pregnancy in a prospectively assembled cohort of 3029 consecutive subfertile couples. Women had to be ovulatory and had to have at least one patent tube, whereas men had to have a normal semen analysis. Time to spontaneous ongoing pregnancy within 12 months was the primary endpoint. Results: The probability of a spontaneous pregnancy declined linearly with a body mass index (BMI) over 29 kg/m(2). Corrected for possible related factors, women with a high BMI had a 4% lower pregnancy rate per kg/m(2) increase [hazard ratio: 0.96 (95% CI 0.91-0.99)]. Conclusions: These results indicate that obesity is associated with lower pregnancy rates in subfertile ovulatory women.

引用

页码：324 / 328

页数：5

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