Statin therapy and the acute inflammatory response after coronary artery bypass grafting

被引：49

作者：

Brull, DJ

Sanders, J

Rumley, A

Lowe, GDO

Humphries, SE

Montgomery, HE

机构：

[1] UCL Royal Free & UCL Med Sch, Dept Med, British Heart Fdn Labs, Ctr Cardiovasc Genet, London WC1E 6JJ, England

[2] Glasgow Royal Infirm, Dept Med, Glasgow G4 0SF, Lanark, Scotland

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2001年 / 88卷 / 04期

关键词：

D O I：

10.1016/S0002-9149(01)01696-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Preoperative statin therapy has been shown to improve cardiovascular outcome after coronary artery bypass grafting; however, the clinical gain achieved is in excess of the reduction in lipids. We demonstrate that statin therapy exerts a direct anti-inflammatory effect mediated through reduced interleukin-6 production.

引用

页码：431 / +

页数：4

共 12 条

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