No evidence for association of 12p13 SNPs rs11833579 and rs12425791 within NINJ2 gene with ischemic stroke in Chinese Han population

被引：30

作者：

Ding, Hu ^{[2
,4
]}

Tu, Xin ^{[1
,3
]}

Xu, Yujun ^{[2
,4
]}

Xu, Chenqi ^{[1
,3
]}

Wang, Xiaojing ^{[5
]}

Cui, Guanglin ^{[2
,4
]}

Bao, Xunna ^{[2
,4
]}

Hui, Rutai ^{[6
,7
]}

Wang, Qing K. ^{[1
,3
]}

Wang, Dao Wen ^{[2
,4
]}

机构：

[1] Huazhong Univ Sci & Technol, Key Lab Mol Biophys, Minist Educ, Coll Life Sci & Technol,Cardiox Ctr, Wuhan 430074, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Internal Med, Wuhan 430074, Peoples R China

[3] Huazhong Univ Sci & Technol, Ctr Human Genome Res, Wuhan 430074, Peoples R China

[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Inst Hypertens, Wuhan 430074, Peoples R China

[5] Univ Pittsburgh, Ctr Craniofacial & Dent Genet, Sch Dent Med, Pittsburgh, PA 15219 USA

[6] Chinese Acad Med Sci, Beijing 100730, Peoples R China

[7] Fuwai Hosp, Peking Union Med Coll, Beijing, Peoples R China

来源：

ATHEROSCLEROSIS | 2011年 / 216卷 / 02期

关键词：

Stroke; 12p13; Chinese Han population; RISK; POLYMORPHISM;

D O I：

10.1016/j.atherosclerosis.2011.02.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent genome-wide association (GWA) studies have identified two intergenic single nucleotide polymorphisms (SNPs) (rs11833579 and rs12425791) on chromosome 12p13 and within 11 kb of the NINJ2 gene that were significantly associated with stroke in Caucasians. However, the validity of the association has remained controversial. We performed genetic association analyses in three independent cohorts, including total of 3042 cases and 2973 controls. No significant association between these two SNPs and ischemic stroke was detected by meta-analysis after adjustment for cardiovascular risk factors under the additive model. Our data does not support that the common variants on 12p13 are major contributors of ischemic stroke in the Chinese Han population. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：381 / 382

页数：2

共 9 条

[1]

[Anonymous], 2010, N ENGL J MED, V362, P1547

[2] Genome-Wide Association Studies of MRI-Defined Brain Infarcts Meta-Analysis From the CHARGE Consortium [J].

Debette, Stephanie ;

Bis, Joshua C. ;

Fornage, Myriam ;

Schmidt, Helena ;

Ikram, M. Arfan ;

Sigurdsson, Sigurdur ;

Heiss, Gerardo ;

Struchalin, Maksim ;

Smith, Albert V. ;

van der Lugt, Aad ;

DeCarli, Charles ;

Lumley, Thomas ;

Knopman, David S. ;

Enzinger, Christian ;

Eiriksdottir, Gudny ;

Koudstaal, Peter J. ;

DeStefano, Anita L. ;

Psaty, Bruce M. ;

Dufouil, Carole ;

Catellier, Diane J. ;

Fazekas, Franz ;

Aspelund, Thor ;

Aulchenko, Yurii S. ;

Beiser, Alexa ;

Rotter, Jerome I. ;

Tzourio, Christophe ;

Shibata, Dean K. ;

Tscherner, Maria ;

Harris, Tamara B. ;

Rivadeneira, Fernando ;

Atwood, Larry D. ;

Rice, Kenneth ;

Gottesman, Rebecca F. ;

van Buchem, Mark A. ;

Uitterlinden, Andre G. ;

Kelly-Hayes, Margaret ;

Cushman, Mary ;

Zhu, Yicheng ;

Boerwinkle, Eric ;

Gudnason, Vilmundur ;

Hofman, Albert ;

Romero, Jose R. ;

Lopez, Oscar ;

van Duijn, Cornelia M. ;

Au, Rhoda ;

Heckbert, Susan R. ;

Wolf, Philip A. ;

Mosley, Thomas H. ;

Seshadri, Sudha ;

Breteler, Monique M. B. .

STROKE, 2010, 41 (02) :210-217

[3] A Novel Loss-of-Function DDAH1 Promoter Polymorphism Is Associated With Increased Susceptibility to Thrombosis Stroke and Coronary Heart Disease [J].

Ding, Hu ;

Wu, Bin ;

Wang, Hu ;

Lu, Zhilan ;

Yan, Jiangtao ;

Wang, Xiaojing ;

Shaffer, John R. ;

Hui, Rutai ;

Wang, Dao Wen .

CIRCULATION RESEARCH, 2010, 106 (06) :1145-U312

[4] Risk Variants for Atrial Fibrillation on Chromosome 4q25 Associate with Ischemic Stroke [J].

Gretarsdottir, Solveig ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Sryrkarsdottir, Unnur ;

Helgadottir, Anna ;

Gschwendtner, Andreas ;

Kostulas, Konstantinos ;

Kuhlenbaeumer, Gregor ;

Bevan, Steve ;

Jonsdottir, Thorbjorg ;

Bjarnason, Hjordis ;

Saemundsdottir, Jona ;

Palsson, Stefan ;

Arnar, David O. ;

Holm, Hilma ;

Thorgeirsson, Gudmundur ;

Valdimarsson, Einar Mar ;

Sveinbjoernsdottir, Sigurlaug ;

Gieger, Christian ;

Berger, Klaus ;

Wichmann, H-Erich ;

Hillert, Jan ;

Markus, Hugh ;

Gulcher, Jeffrey Robert ;

Ringelstein, E. Bernd ;

Kong, Augustine ;

Dichgans, Martin ;

Gudbjartsson, Daniel Fannar ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

ANNALS OF NEUROLOGY, 2008, 64 (04) :402-409

[5] Genetics and ischaemic stroke [J].

Hassan, A ;

Markus, HS .

BRAIN, 2000, 123 :1784-1812

[6] Genetic risk factors for stroke and carotid atherosclerosis: insights into pathophysiology from candidate gene approaches [J].

Humphries, SE ;

Morgan, L .

LANCET NEUROLOGY, 2004, 3 (04) :227-236

[7] Genomewide Association Studies of Stroke [J].

Ikram, M. Arfan ;

Seshadri, Sudha ;

Bis, Joshua C. ;

Fornage, Myriam ;

DeStefano, Anita L. ;

Aulchenko, Yurii S. ;

Debette, Stephanie ;

Lumley, Thomas ;

Folsom, Aaron R. ;

van den Herik, Evita G. ;

Bos, Michiel J. ;

Beiser, Alexa ;

Cushman, Mary ;

Launer, Lenore J. ;

Shahar, Eyal ;

Struchalin, Maksim ;

Du, Yangchun ;

Glazer, Nicole L. ;

Rosamond, Wayne D. ;

Rivadeneira, Fernando ;

Kelly-Hayes, Margaret ;

Lopez, Oscar L. ;

Coresh, Josef ;

Hofman, Albert ;

DeCarli, Charles ;

Heckbert, Susan R. ;

Koudstaal, Peter J. ;

Yang, Qiong ;

Smith, Nicholas L. ;

Kase, Carlos S. ;

Rice, Kenneth ;

Haritunians, Talin ;

Roks, Gerwin ;

de Kort, Paul L. M. ;

Taylor, Kent D. ;

de Lau, Lonneke M. ;

Oostra, Ben A. ;

Uitterlinden, Andre G. ;

Rotter, Jerome I. ;

Boerwinkle, Eric ;

Psaty, Bruce M. ;

Mosley, Thomas H. ;

van Duijn, Cornelia M. ;

Breteler, Monique M. B. ;

Longstreth, W. T., Jr. ;

Wolf, Philip A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (17) :1718-1728

[8] A genome-wide genotyping study in patients with ischaemic stroke:: initial analysis and data release [J].

Matarin, Mar ;

Brown, W. Mark ;

Scholz, Sonja ;

Simon-Sanchez, Javier ;

Fung, Hon-Chung ;

Hernandez, Dena ;

Gibbs, J. Raphael ;

De Vrieze, Fabienne Wavrant ;

Crews, Cynthia ;

Britton, Angela ;

Longefeld, Carl D. ;

Brott, Thomas G. ;

Brown, Robert D., Jr. ;

Worrall, Bradford B. ;

Frankel, Michael ;

Silliman, Scott ;

Case, L. Douglas ;

Singleton, Andrew ;

Hardy, John A. ;

Rich, Stephen S. ;

Meschia, James F. .

LANCET NEUROLOGY, 2007, 6 (05) :414-420

[9] Minor Allele C of Chromosome 1p32 Single Nucleotide Polymorphism rs11206510 Confers Risk of Ischemic Stroke in the Chinese Han Population [J].

Xu, Chengqi ;

Wang, Fan ;

Wang, Binbin ;

Li, Xiuchun ;

Li, Cong ;

Wang, Dan ;

Xiong, Xin ;

Wang, Pengyun ;

Lu, Qiulun ;

Wang, Xiaojing ;

Yang, Qin ;

Yin, Dan ;

Huang, Yufeng ;

Ji, Liying ;

Wang, Nan ;

Chen, Shanshan ;

Cheng, Xiang ;

Liao, Yuhua ;

Ma, Xu ;

Su, Dingfeng ;

Chen, Guohua ;

Xia, Hao ;

Shi, Lisong ;

Tu, Xin ;

Wang, Qing K. .

STROKE, 2010, 41 (08) :1587-1592

← 1 →